SOD-瓒呮哀鍖栫墿姝у寲閰舵祴瀹氳瘯鍓傜洅(閭昏嫰涓夐厷搴曠墿娉?
--鍙嶆槧鏈轰綋鍐呰嚜鐢卞熀鍚噺鐨勯噸瑕佹寚鏍嘃/h3>
鏍锋湰绫诲瀷锛氭柊椴滄棤婧惰琛€娓呮垨EDTA鎶楀嚌琛€娴咟/p>
閫傜敤浠櫒锛氭湰璇曞墏鐩掗€傜敤浜庣粷澶у鏁颁富娴佺敓鍖栧垎鏋愪华
璇曞墏鐩掍紭鍔军/h4>
1.閰舵硶娴嬪畾锛岀伒鏁忓害楂橈紝鎶楀共鎵拌兘鍔涘己
2.绾挎€ц寖鍥村锛?5锝?50 U/mL
鎸囨爣绠€浠婞/h3>
瓒呮哀鍖栫墿姝у寲閰?SOD)鏄竴绉嶇壒娈婄殑閲戝睘閰讹紝瀹冭兘鍌寲瓒呮哀闃寸瀛愯嚜鐢卞熀(O2)鍙戠敓宀愬寲鍙嶅簲锛屼粠鑰岃兘鏈夋晥娓呴櫎鏈轰綋鍐呰秴姘ч槾绂诲瓙鑷敱鍩?O2)锛屾槸鐢熺墿浣撻噸瑕佺殑缁嗚優闃插尽绯荤粺涔嬩竴锛屽叿鏈夐槻寰℃哀姣掋€佹姉杈愬皠銆侀槻琛拌€佷互鍙婇槻娌昏偪鐦ゅ拰鎶楃値绛夎嵂鐢ㄥ姛鏁堛€傚SOD鐨勬娴嬶紝鍙互闂存帴浜嗚В鏈轰綋閬嚜鐢卞熀鎹熶激浠ュ強瀵规姉鑷敱鍩烘崯浼や袱鑰呬箣闂寸殑鍏崇郴[1,2]銆侟/p>
妫€娴嬪師鐞咟/h3>
鍦ㄦ牱鏈腑瓒呮哀鍖栫墿姝у寲閰跺偓鍖栦綔鐢ㄤ笅锛岃秴姘ч槾绂诲瓙鑷敱鍩哄彂鐢熸鍖栧弽搴旓紝鐢熸垚杩囨哀鍖栨阿鍜屾哀姘斻€傚湪纰辨€ф潯浠朵笅锛岄偦鑻笁閰氫細浜х敓鑷哀鍖栨樉鑹插弽搴旓紝鏄捐壊寮哄害鍚岃秴姘у寲鐗╂鍖栭叾鐨勬椿鎬ф垚姝f瘮锛岄€氳繃娴嬪畾棰滆壊鍙樺寲锛屽彲浠ヨ绠楀嚭鏍锋湰涓秴姘у寲鐗╂鍖栭叾鐨勬椿鎬с€侟/p>
涓村簥搴旂敤
- SOD甯哥敤浜庡缂鸿銆佸嚭琛€鎬у績銆佽剳銆佽偩銆佽倽銆佽偤绛夐噸瑕佽剰鍣ㄧ梾鍙?鎴栨墜鏈不鐤楀悗)寮曞彂鐨勭户鍙戞€?鑷敱鍩?杩囨哀鍖栨崯浼ゅ強鍏惰嚜鐢卞熀娓呴櫎鑽墿娌荤枟鏁堟灉鐨勭洃娴嬶紝浠ユ寚瀵间复搴婂埗瀹氱浉搴旂殑鑷敱鍩烘竻闄ゅ共棰勫绛栧強鏈€浣虫不鐤楁椂闂寸獥鍙g殑纭珛锛屽畠瀵硅嚜鐢卞熀缁у彂鎹熶激鐥呮儏鐨勮瘖鏂€佽嚜鐢卞熀娓呴櫎娌荤枟鐤楁晥璺熻釜鍜岄鍚庡垽鏂笌璇勪及绛夊叿鏈夐噸瑕佸弬鑰冧环鍊笺€係OD娴嬪畾铏芥槸涓€绉嶉潪鐗瑰紓鐨勮緟鍔╄瘖鏂寚鏍囷紝浣嗗鏈轰綋鑷敱鍩轰唬璋㈢磰涔便€佽嚜鐢卞熀娓呴櫎骞查瀵圭瓥銆佷互鍙婂浜庡悓涓€鐥呮偅鑰呯梾绋嬭浆褰?鑷敱鍩烘崯浼ょ殑鍔犲墽鎴栭檷浣庛€佽嚜鐢卞熀娓呴櫎鍓傝嵂鐗╂垨鎵嬫湳娌荤枟鏁堟灉)鐨勫垽鏂紝瀵逛复搴婁笂鎬ャ€佹參鎬х柧鐥呯殑鐤楁晥瑙傚療銆侀鍚庝互鍙婂苟鍙戠棁鐨勯娴嬪叿鏈夊緢寮虹殑鍙傝€冧环鍊笺€侟/li>
- 鐢熺悊鎬ч檷浣庯細鈶犳満浣撴姉姘у寲钀ュ吇绱犳憚鍏ヤ笉瓒冲VitE銆乂itA,VtC銆丅-鑳¤悵鍗滅礌銆佺銆侀摐銆侀攲銆侀敯绛夌己涔忥紝纭掓槸GSHPS鐨勭粍鎴愰儴鍒嗭紝閾溿€侀攲鏄疌u/Zn-SOD鐨勬垚鍒嗭紝閿版槸Mn-SOD鐨勬垚鍒嗐€傗憽涓€鑸€佸勾浜烘竻闄ら叾娲诲姏闄嶄綆鑰佸勾浜烘柊闄堜唬璋㈠姛鑳戒笅闄嶏紝閰惰瀵肩敓鎴愬噺灏戯紝涓嶈兘缁存寔鑷敱鍩虹殑浣庢祿搴﹀姩鎬佸钩琛°€侟/li>
- 鐥呯悊鎬ч檷浣庯細鈶犺剳閮ㄧ缁忕柧鐥咃細鎬ユ€ц剳姊楁銆佽剳鍑鸿銆佽洓缃戣啘涓嬭厰鍑鸿銆丠E銆傚浼わ細棰呰剳鎹熶激銆傗憽缂鸿鎬у績鑴忕梾锛氬績鑲岀己琛€(鍐犵姸鍔ㄨ剦绮ョ姸纭寲鎬у績鑴忕梾)銆佹€ユ€у績鑲屾濉炪€傗憿鍖诲鎵嬫湳鏁戞不娌荤枟鍚庣户鍙戞崯浼ゃ€傗懀鑲跨槫锛歋OD鐨勮〃杈炬按骞充笌鑲虹檶鎮h€呯殑棰勫悗瀵嗗垏鐩稿叧锛岄珮SOD琛ㄨ揪缁勭殑鎮h€呮槑鏄剧敓瀛樻湡鏇撮暱[3]銆侟/li>
- 鐢熺悊鎬у楂橈細闀挎椂闂村婧愭€у鍔犺繃澶歋OD锛屾満浣撳皢涓嶈兘缁存寔涓€瀹氶噺鐨勮嚜鐢卞熀姘村钩锛屽厤鐤粏鑳炰娇鐢ㄨ嚜鐢卞熀浣滀负涓€涓柟娉曟墽琛屽叾鍏嶇柅鍔熻兘锛岃繃浣庣殑鑷敱鍩轰細寮曡捣鐢熺悊鐢熷寲杩囩▼澶卞父锛岀牬鍧忔甯哥殑鐢熺悊鍔熻兘锛屽锛氭満浣撹В姣掋€佸悶鍣姛鑳戒笅闄嶃€佸嚌琛€杩囩▼鍙楅樆鍙婅兌鍘熻泲鐧姐€佸墠鍒楄吅绱犮€佺幆鏍歌嫹閰稿悎鎴愬彈鎹熺瓑锛屽苟寮曡捣涓ラ噸鐨勬瘨鍓綔鐢ㄣ€侟/li>
- 鐥呯悊鎬у楂橈細鍦ㄦ€ユ€х梾鎮e彂鐢熷垵鏈燂紝褰撴満浣撹嚜鐢卞熀浜х敓澶у箙杩囧婵€澧炴椂锛屾満浣撲細寰堝揩寮曡捣姘у寲搴旀縺锛屽苟褰卞搷鍒拌泲鐧借川琛ㄨ揪绛夎皟鑺傘€佸簲绛旀満鍒躲€傚湪鑷敱鍩虹殑璇卞鍙婃満浣撲唬鍋垮簲婵€涓嬶紝缁嗚優鎴栨満浣撲細璇卞鎬у湴澧炲己鎶楁哀鍖栬兘鍔涳紝涓€鑸細鍑虹幇涓€杩囨€OD姘村钩澧為珮鐜拌薄銆備絾闅忕潃楂樻祿搴﹁嚜鐢卞熀瀵筍OD鐨勫ぇ閲忔秷鑰楋紝浠ュ強鏈轰綋鐨勫け浠e伩锛孲OD鐨勭敓鐗╁悎鎴愯兘鍔涗細寰堝揩鍥炶惤鍒颁綆姘村钩锛屽苟涓庤緝楂樻祿搴︾殑鑷敱鍩轰繚鎸佹柊鐨勫姩鎬佸钩琛°€侟/li>
閫傜敤绉戝
绉戝 |
涓村簥搴旂敤 |
妫€楠屼腑蹇傸/strong> |
鍙垪鍏ュ父瑙勭殑浣撴濂楅涓紝鍗忓姪璇婃柇澶氱鐤剧梾锛屽垽鏂仴搴风姸鍐袋/p> |
蹇冭绠″唴绉慄/strong> |
鍙敤浜庢€ユ€у績鑲屾姝荤殑閴村埆璇婃柇 |
鍎跨 |
鐢ㄤ簬鏂扮敓鍎跨己琛€缂烘哀鎬ц剳鐥呯殑璇婃柇鍙婇鍚庣殑鐩戞祴 |
濡囩 |
鐢ㄤ簬璇婃柇瀛愬鍐呰啘寮備綅鐥囩殑鍙戠敓鍙戝睍鐘跺喌 |
澶栫 |
鍙敤浜庢娴嬫墜鏈悗姘ц嚜鐢卞熀鐨勫彉鍖栨儏鍐碉紝杩涜€屽垽鏂湳鍚庢偅鑰呯殑鎭㈠鐘跺喌 |
鍐呭垎娉岀 |
鐢ㄤ簬璇婃柇绯栧翱鐥咃紝绯栧翱鐥呰偩鐥咃紝甯姪閲囧彇鏇存湁鏁堢殑涓村簥骞查鎺柦 |
鍙傝€冩枃鐚?/h3>
[1] 璁哥敵楦?鏉憵,鏉庤繍骞?瓒呮哀鍖栫墿姝у寲閰堕偦鑻笁閰氭祴娲绘硶鐨勭爺绌跺強鏀硅繘[J].鍖栧閫氭姤, 2001(8):516-519.
[2] 璁搁泤濞?璧佃壋鏅?鑳¤櫣.閭昏嫰涓夐厷鑷哀鍖栨硶娴嬪畾瓒呮哀鍖栫墿姝у寲閰舵椿鎬х殑鐮旂┒[J].瑗垮崡姘戞棌澶у瀛︽姤锛氳嚜鐒剁瀛︾増, 2006(6):4.
[3] Roberta, et al., Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE. Journal of Biological Chemistry, 2016.
鎸囧崡鍏辫瘑

鐩稿叧浜у搧
