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妫€娴嬪師鐞咟/h3>
1.璇曞墏1涓殑闈炵瀛愯〃闈㈡椿鎬ф垚浠戒娇琛€娓呬腑鐨勫皬鑰屽瘑浣庡瘑搴﹁剛铔嬬櫧鍙楀埌鎶戝埗锛岃€岄珮瀵嗗害鑴傝泲鐧姐€佸ぇ鑰岃交浣庡瘑搴﹁剛铔嬬櫧銆佷腑瀵嗗害鑴傝泲鐧姐€佷钩绯滃井绮掑拰鏋佷綆瀵嗗害鑴傝泲鐧界粡鑳嗗浐閱囬叾鍙嶅簲娑堣€楁帀锛岀敱浜庣己涔忎竴涓壊婧愯€屼笉鏄捐壊銆?.璇曞墏2涓殑琛ㄩ潰娲绘€у墏閲婃斁鍑哄皬鑰屽瘑浣庡瘑搴﹁剛铔嬬櫧鍚庯紝浠呭sdLDL-C杩涜娴嬪畾銆侟/p>
涓村簥搴旂敤
- sdLDL鏄疞DL涓績杩涘姩鑴夌播鏍风‖鍖栧彂鐢熴€佸彂灞曠殑涓昏浜氬瀷銆傚叿鏈夌浉杩慙DL姘村钩浣哃DL浜氱粍鍒嗗挨鍏舵槸sdLDL姘村钩涓嶅悓鐨勪汉缇ゅ彂鐢烝SCVD鐨勯闄╀笉鍚孅span style="color:hsl(212,80%,42%);">[2]銆傜敱浜巗dLDL涓儐鍥洪唶鍚噺姣旇緝绋冲畾锛屼复搴婁笂甯搁€氳繃妫€娴嬪皬鑰屽瘑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱?sdLDL鈥慍)鍚噺闂存帴浜嗚В琛€娴唖dLDL鍚噺銆傚垎鏋愬苟鎺㈣sdLDL-C姘村钩鐨勫彉鍖栬姣斿崟绾祴瀹歀DL-C鍏锋湁鏇撮噸瑕佺殑涓村簥鍙傝€冧环鍊笺€俿dLDL-C娴嬪畾鏈夊姪浜嶢SCVD 椋庨櫓璇勪及鍙婄浉鍏崇柧鐥呬弗閲嶇▼搴︾殑鍒ゆ柇[3]銆侟/li>
- sdLDL-C涓庡啝鐘跺姩鑴夌嫮绐勭▼搴﹀叧绯诲瘑鍒囷細澶ч噺鐮旂┒宸茶瘉瀹烇紝sdLDL-C鏄姩鑴夌播鏍风‖鍖栨€у績琛€绠＄柧鐥?ASCVD)鐨勭嫭绔嬪嵄闄╁洜绱狅紝sdLDL-C姘村钩鏈夊姪浜庣浉鍏崇梾鍙樹弗閲嶇▼搴︾殑璇勪及[4,5]銆侟/li>
- sdLDL-C鏄瘎浼板啝蹇冪梾(CHD)椋庨櫓鐨勬洿濂芥寚鏍囷細瓒婃潵瓒婂鐨勭爺绌惰瘉瀹烇紝sdLDL-C鏄疌HD椋庨櫓,寮烘湁鍔涗笖鐙珛鐨勯娴嬪洜瀛忺span style="color:hsl(212,80%,42%);">[6]銆侟/li>
- sdLDL-C涓庨珮琛€鍘嬶細Li绛堻span style="color:hsl(212,80%,42%);">[7]鍙戠幇sdLDL-C娴撳害鍙嫭绔嬮娴嬫甯歌鍘嬪彈璇曡€呯殑鍔ㄨ剦鍍电‖杩涘睍銆傛澶栵紝鐮旂┒鍙戠幇锛岃娓卻dLDL-C姘村钩涓庤娑查粡搴︾嫭绔嬬浉鍏筹紝鍙綔涓洪珮琛€鍘嬫偅鑰匒SCVD鍗遍櫓璇勪及鐨勫彲闈犳寚鏍囥€傛垜鍥戒竴椤瑰楂樿鍘嬩汉缇ょ殑闅忚鐮旂┒鏄剧ず锛宻dLDL-C鏄珮琛€鍘嬫偅鑰呬富瑕佷笉鑹績琛€绠′簨浠剁殑鍗遍櫓鍥犵礌[8]銆侟/li>
- sdLDL-C涓庝唬璋㈢患鍚堝緛銆佺硸灏跨梾锛歴dLDL-C鐨勬祴瀹氭湁鍔╀簬璇勪及涓庝唬璋㈢患鍚堝緛鐩稿叧鐨勯闄?span style="color:hsl(212,80%,42%);">[9]銆傛潕绾㈤湠绛夌爺绌跺彂鐜帮紝2鍨嬬硸灏跨梾(2DM)鐥呬汉琛€娓呬腑鐨剆dLDL-C姘村钩鏄捐憲鍗囬珮锛屼笌DM鐨勫彂鐢熶互鍙婁弗閲嶇▼搴﹀叿鏈夋樉钁楃浉鍏虫€э紝闄嶈剛鑽墿娌荤枟缁勬瘮鏈不鐤楃粍鐨剆dLDL-C姘村钩鏄庢樉闄嶄綆[10]銆傞儙鎱ц姵绛夌爺绌跺彂鐜帮紝sdLDL-C鏄?鍨嬬硸灏跨梾鎮ｈ€呴鍔ㄨ剦绮ユ牱纭寲鐨勭嫭绔嬪嵄闄╁洜绱燑span style="color:hsl(212,80%,42%);">[11]銆侟/li>
- sdLDL-C涓庤剳鍗掍腑锛歓hou P绛堻span style="color:hsl(212,80%,42%);">[12]鐮旂┒鍙戠幇锛宻dLDL-C浣滀负鐙珛鍗遍櫓鍥犵礌锛屽浜庤瘎浼版€ユ€х己琛€鎬у崚涓?AIS)椋庨櫓鍜岄鍚庡叿鏈夐噸瑕佹剰涔夈€傚彟涓€椤归拡瀵圭煭鏆傛€ц剳缂鸿鍙戜綔(TIA)鎮ｈ€呯殑鐮旂┒鍙戠幇锛宻dLDL-C姘村钩涓嶵IA鍚庡啀鍙戝崚涓闄╂鐩稿叧锛岃娓卻dLDL-C姘村钩鍗囬珮鏈夋湜鎴愪负TIA鎮ｈ€呭啀鍙戝崚涓闄╄瘎浼扮殑鏂版寚鏍嘃span style="color:hsl(212,80%,42%);">[13]銆侟/li>
- sdLDL-C涓庢參鎬ц偩鑴忕梾锛歴dLDL-C姘村钩鐨勫崌楂樹笌鎱㈡€ц偩鍔熻兘涓嶅叏瀵嗗垏鐩稿叧銆侰hu M绛夌爺绌跺彂鐜?span style="color:hsl(212,80%,42%);">[14]锛孋KD鎮ｈ€呯殑sdLDL鍜宻dLDL/LDL姣斿€兼槑鏄惧崌楂樸€侶ao Shen绛堻span style="color:hsl(212,80%,42%);">[15]鐮旂┒鍙戠幇锛宻dLDL-C鍜宻dLDL-C/LDL-C鏄參鎬ц偩鑴忕梾(CKD)鎮ｈ€呭績琛€绠′簨浠剁殑鐙珛鍗遍櫓鍥犵礌锛宻dLDL-C>38mg鍜宻dLDL-C/LDL-C>0.3涓庡績琛€绠′簨浠舵槑鏄剧浉鍏炽€侟/li>
- sdLDL-C姘村钩闄嶄綆鎯呭喌锛歴dLDL-C姘村钩鍋忎綆鍙兘涓庝竴浜涚柧鐥呭洜绱犳垨闈炵柧鐥呭洜绱犳湁鍏炽€傜柧鐥呭洜绱犲彲鑳藉寘鎷棤β-鑴傝泲鐧借鐥?ABL)銆侀珮娑堣€楃柧鐥呭鐢茬姸鑵哄姛鑳戒孩杩涖€佽倽纭寲鍜屾伓鎬ц偪鐦ょ瓑;鍦ㄨ繖浜涙儏鍐典笅锛屾偅鑰呮満浣撳唴鐨勮儐鍥洪唶鍜岃泲鐧借川娑堣€楅噺杈冨ぇ锛屼粠鑰屽鑷磋涓璍DL鐨勫惈閲忛檷浣庯紝杩涜€屼娇sdLDL-C姘村钩闄嶄綆銆傞潪鐤剧梾鍥犵礌鍙兘鍖呮嫭钀ュ吇鎽勫叆涓嶈冻鎴栧墽鐑堣繍鍔ㄧ瓑锛岃繖浜涘洜绱犲彲鑳藉鑷磗dLDL-C姘村钩闄嶄綆锛屼絾閫氬父琚涓烘槸姝ｅ父鐢熺悊鐜拌薄锛屽簲娉ㄦ剰璋冩暣楗鍜岄€傚綋杩愬姩鍔犱互鏀瑰杽銆侟/li>
閫傜敤绉戝
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閫傜敤绉戝 |
閫傛浜虹兢 |
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鍐呯/蹇冨唴绉慄/strong> |
锛?锛夋湁 ASCVD 鐥呭彶鑰咃紝鍖呮嫭蹇冭倢姊楁銆佸啝鐘跺姩鑴夋垨鍏朵粬琛€绠￠噸寤烘墜鏈€佺煭鏆傛€ц剳缂鸿鍙戜綔銆佺己琛€鎬у崚涓€佸鍛ㄥ姩鑴夌播鏍风‖鍖栨€х柧鐥呯瓑鎮ｈ€呫€傦紙2锛夊瓨鍦ㄥ椤 ASCVD 鍗遍櫓鍥犵礌鐨勪汉缇わ紝濡傞珮琛€鍘嬨€佺硸灏跨梾銆佽偉鑳栥€佸惛鐑熻€呯瓑銆傦紙3锛夋湁鏃╁彂 CVD 瀹舵棌鍙茶€咃紝鍗崇敺鎬т竴绾х洿绯讳翰灞炲湪 55 宀佸墠鎴栧コ鎬т竴绾х洿绯讳翰灞炲湪65 宀佸墠鎮 ASCVD锛屾垨鏈夊鏃忔€ч珮鑴傝鐥囨偅鑰呫€傦紙4锛夊鏃忔€ф棤β鎴栦綆β鑴傝泲鐧借鐥囨偅鑰呫€侟/p> |
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鑲剧梾绉?鑲惧唴绉慄/strong> |
鎱㈡€ц偩鍔熻兘涓嶅叏銆佸悇绉嶆€ユ參鎬ц偩鑴忕梾 |
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鐨偆绉慄/strong> |
鐨偆鎴栬倢鑵遍粍鑹茬槫鍙婅窡鑵卞鍘氳€匋/p> |
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娑堝寲绉?鑲濊儐鍐呯 |
娑堝寲鍚告敹涓嶈壇銆佽倽纭寲绛堻/p> |
|
濡囦骇绉慄/strong> |
瀛曚骇濡嘃/p> |
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鑲跨槫绉慄/strong> |
澶氬彂鎬ч楂撶槫銆佹穻宸寸槫銆佷钩鑵虹檶绛夋伓鎬т腑璺偅鑰匋/p> |
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鍐呭垎娉岀 |
鐢茬姸鑵哄姛鑳戒孩杩汓/p> |
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钀ュ吇绉慄/strong> |
钀ュ吇涓嶈壇 |
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浣撴绉?浣撴涓績 |
鏅€氫綋妫€浜虹兢 |
鍙傝€冩枃鐚?/h3>
[1] 鏈ㄩ偅鐡﹀皵·鍏嬬儹鏈?杩媺鐑?middot;闃胯开,榄忓ù,绛? 灏忚€屽瘑浣庡瘑搴﹁剛铔嬬櫧涓庡績琛€绠＄柧鐥呯浉鍏虫€х殑鐮旂┒杩涘睍[J]. 涓浗蹇冭绠℃潅蹇?2023,28(6):583-587.
[2] Sakurai T, Takeda S, Takahashi JY, Takahashi Y, Wada N, Trirongjitmoah S, Namita T, Jin S, Ikuta A, Furumaki H, Hui SP, Fuda H, Fujikawa M, Shimizu K, Chiba H. Measurement of single low-density lipoprotein particles by atomic force microscopy. Ann Clin Biochem. 2013 Nov;50(Pt 6):564-70.
[3] 涓浗琛€鑴傜鐞嗘寚鍗椾慨璁㈣仈鍚堜笓瀹跺鍛樹細. 涓浗琛€鑴傜鐞嗘寚鍗?2023骞?[J]. 涓崕蹇冭绠＄梾鏉傚織,2023,51(3):221-255.
[4] Goel PK, Ashfaq F, Khanna R, Ramesh V, Pandey CM. The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients. Indian J Clin Biochem. 2017 Jun;32(2):186-192.
[5] Pan Z, Guo H, Wang Q, Tian S, Zhang X, Li C, Ma Z. Relationship between subclasses low-density lipoprotein and carotid plaque. Transl Neurosci. 2022 Mar 3;13(1):30-37.
[6] 瀹夊畞,閭瑰痉鐜? 灏忚€屽瘑浣庡瘑搴﹁剛铔嬬櫧涓庡啝蹇冪梾鐨勭爺绌惰繘灞昜J]. 涓浗鍔ㄨ剦纭寲鏉傚織,2019,27(7):639-644.
[7] Li G, Wu HK, Wu XW, Cao Z, Tu YC, Ma Y, Wang WQ, Cheng J, Zhou ZH. Small dense low density lipoprotein-cholesterol and cholesterol ratios to predict arterial stiffness progression in normotensive subjects over a 5-year period. Lipids Health Dis. 2018 Feb 12;17(1):27.
[8] 璧靛噷椋?寮犻噾鏋?钖涗匠濠?绛? 灏忚€屽瘑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囩殑鐮旂┒鐜扮姸[J]. 鍖诲淇℃伅,2022,35(2):39-42.
[9] Fan J, Liu Y, Yin S, Chen N, Bai X, Ke Q, Shen J, Xia M. Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation. Nutr Metab (Lond). 2019 Jan 21;16:7.
[10] 鏉庣孩闇?鏉庝紛鍑?鏉庣強鐝?绛? 灏忚€屽瘑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囪娓呮按骞充笌2鍨嬬硸灏跨梾鐩稿叧鎬х爺绌禰J]. 绮惧噯鍖诲鏉傚織,2018,33(6):474-477.
[11] 閮庢収鑺?鏉庣孩姊? 琛€娓呭皬鑰屽瘑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囦笌2鍨嬬硸灏跨梾鎮ｈ€呴鍔ㄨ剦鐥呭彉涓ラ噸绋嬪害鐨勭浉鍏虫€J]. 涓浗鍖昏嵂鎸囧崡,2020,18(34):22-24.
[12] Zhou P, Liu J, Wang L, Feng W, Cao Z, Wang P, Liu G, Sun C, Shen Y, Wang L, Xu J, Meng P, Li Z, Xu WY, Lan X. Association of Small Dense Low-Density Lipoprotein Cholesterol with Stroke Risk, Severity and Prognosis. J Atheroscler Thromb. 2020 Dec 1;27(12):1310-1324.
[13] 鍚村槈,鏃舵案杈?绋嬪┃,绛? 鐭殏鎬ц剳缂鸿鍙戜綔鎮ｈ€呰娓呭皬鑰屽瘑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囨按骞冲崌楂樹笖涓庡啀鍙戝崚涓闄╃浉鍏崇殑鐮旂┒[J]. 涓崕妫€楠屽尰瀛︽潅蹇?2018,41(4):316-320.
[14] Terkeltaub R, Baird S, Sears P, Santiago R, Boisvert W. The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis. Arthritis Rheum. 1998 May;41(5):900-9.
[15] Shen H, Xu Y, Lu J, Ma C, Zhou Y, Li Q, Chen X, Zhu A, Shen G. Small dense low-density lipoprotein cholesterol was associated with future cardiovascular events in chronic kidney disease patients. BMC Nephrol. 2016 Oct 6;17(1):143.
鎸囧崡鍏辫瘑
