PA-鍓嶇櫧铔嬬櫧娴嬪畾璇曞墏鐩?鍏嶇柅姣旀祳娉?
--璇勪环钀ュ吇鐘舵€佸強鑲濆姛鑳界殑鏁忔劅鎸囨爣锛屾晱鎰熺殑璐熸€ユ€ф椂鐩稿弽搴旇泲鐧键/h3>
鏍锋湰绫诲瀷锛氭柊椴滄棤婧惰琛€娓匋/p>
閫傜敤浠櫒锛氭湰璇曞墏鐩掗€傜敤浜庣粷澶у鏁颁富娴佺敓鍖栧垎鏋愪华
璇曞墏鐩掍紭鍔军/h4>
1.鍚湁鎶楄剛娴婂共鎵版垚鍒嗭紝鎶楀共鎵拌兘鍔涘己
2.绮惧瘑搴﹂珮锛孋V≤5%
3.鏍″噯鍝佸畾鍊兼函婧愯嚦鍥介檯鏈夎瘉鍙傝€冪墿璐‥RM-DA470k
鎸囨爣绠€浠婞/h3>
鍓嶇櫧铔嬬櫧 (prealbumin锛孭A)鍙堢О鍓嶆竻铔嬬櫧鎴栬浆鐢茬姸鑵虹礌 (transthyretin锛孴TR)锛岋紝鍒嗗瓙閲忕害55kD锛屽畬鏁寸殑PA鍒嗗瓙涓哄悓婧愬洓鑱氫綋缁撴瀯锛屾瘡涓簹鍩哄惈127涓皑鍩洪吀銆 琛€娴嗗崐琛版湡涓?.9澶╋紝涓鸿倽鑴忕粏鑳炲悎鎴愮殑绯栬泲鐧斤紝鍥犵數娉虫椂杩佺Щ鍦ㄧ櫧铔嬬櫧涔嬪墠鑰屽緱鍚嶃€侾A鐨勭敓鐞嗗姛鑳戒负缁勭粐淇ˉ鏉愭枡鍜岃繍杞借泲鐧键span style="color:hsl(212,80%,42%);">[1]銆侾A涔熸槸涓€绉嶈礋鎬ユ€ф椂鐩稿弽搴旇泲鐧姐€傚湪鏈轰綋搴旀縺鐘舵€佷笅锛岀櫧浠嬬礌IL-6绛夌値鐥囦粙璐ㄤ細涓嬭皟PA姘村钩銆傜敱浜嶱A鍗婅“鏈熶负1.9d锛屾樉钁椾綆浜庢櫘閫氱櫧铔嬬櫧锛堢害20d锛夛紝灏嗗叾搴旂敤浜庝汉浣撹惀鍏昏瘎浠枫€佽倽鍔熻兘鐩戞祴銆佸簲婵€鍙嶅簲寮哄害璇勪及绛夋柟闈㈠線寰€琛ㄧ幇鍑烘洿鍑鸿壊鐨勭伒鏁忓害锛岀洰鍓嶆鍙楀埌澶氫釜瀛︾鐨勯噸瑙嗐€傚墠鐧借泲鐧藉湪琛€娴嗕腑鐨勬祿搴﹀浜庝簡瑙ｈ泲鐧借川鐨勮惀鍏讳笉鑹€佽倽鍔熻兘涓嶅叏锛屾瘮鐧借泲鐧藉拰閾佽泲鐧藉叿鏈夋洿楂樼殑鐏垫晱搴?span style="color:hsl(212,80%,42%);">[2]銆侟/p>
妫€娴嬪師鐞咟/h3>
浜鸿娓呬腑鐨勫墠鐧借泲鐧戒笌璇曞墏涓€傞噺鐨勭壒寮傛€ф姉浣撳弽搴旓紝褰㈡垚涓嶆憾鎬х殑鍏嶇柅澶嶅悎鐗╋紝浣垮弽搴旀恫浜х敓娴婂害锛屽湪鎶椾綋閲忎竴瀹氱殑鏉′欢涓嬶紝娴婂害鐨勯珮浣庝笌琛€娓呬腑鍓嶇櫧铔嬬櫧鐨勫惈閲忓憟姝ｆ瘮銆侟/p>
涓村簥搴旂敤
- l 璇勪环钀ュ吇涓嶈壇锛氫綆姘村钩鐨凱A鍙寚绀鸿泲鐧借川钀ュ吇涓嶈壇銆侾A鍦?00~400mgL涓烘甯革紝100~150mg/L杞诲害钀ュ吇涓嶈壇(杞诲害缂轰箯)锛?0~100mg/L涓害钀ュ吇涓嶈壇(涓害缂轰箯)锛?lt;50mg/L涓ラ噸钀ュ吇涓嶈壇(涓ラ噸缂轰箯)[1]銆傛湁鐮旂┒鏄剧ず锛氳娓呭墠鐧借泲鐧姐€佺粨鍚堢彔铔嬬櫧鍏锋湁楂樺害鏁忔劅鎬э紝鍙綔涓哄嵄閲嶇梾浜烘棭鏈熻惀鍏绘敮鎸佺殑钀ュ吇鎸囨爣锛岃浆閾佽泲鐧藉彲浣滀负涓湡钀ュ吇鏀寔鐨勮惀鍏绘寚鏍嘃span style="color:hsl(212,80%,42%);">[3]銆傚墠鐧借泲鐧藉彲鍙嶆槧鐭湡钀ュ吇鐘跺喌锛屼竴椤瑰墠鐬绘€ч槦鍒楃爺绌舵樉绀猴紝鍓嶇櫧铔嬬櫧姘村钩鏄參鎬ц偩鑴忕梾(CKD)鎮ｈ€?骞存浜＄巼鍜屼綇闄㈢巼鐨勯娴嬪洜瀛忺span style="color:hsl(212,80%,42%);">[4]銆傚墠鐧借泲鐧戒綔涓鸿惀鍏讳笉鑹殑鐢熺墿鏍囧織鐗╋紝鍙綔涓烘墜鏈粨鏋滈鍚庡拰涓ラ噸鐤剧梾姝讳骸鐜囩殑棰勬祴鎸囨爣[5]銆侟/li>
- l 璇勪环鑲濆姛鑳戒笉鍏細鑲濆姛鑳芥崯浼ゆ椂PA闄嶄綆锛屾瘮鐧借泲鐧藉拰杞搧铔嬬櫧鏇存晱鎰燂紝瀵规棭鏈熻倽鐐庡強閲嶇棁鑲濈値鏈夌壒娈婅瘖鏂环鍊稽span style="color:hsl(212,80%,42%);">[1]銆俌asmin 绛堻span style="color:hsl(212,80%,42%);">[6]鐮旂┒鍙戠幇锛屽湪璇勪及鎬ユ€ц倽鎹熶激鏂归潰锛岃娓呭墠鐧借泲鐧芥瘮鐧借泲鐧芥洿涓烘晱鎰熴€備竴鑸湪鎬ユ€ц倽鐐庛€佹€ユ€ч噸鐥囪倽鐐庛€佷簹鎬ユ€ц倽鍧忔鍙婅倽纭寲鏃躲€侀樆濉炴€ч粍鐤告偅鑰呰娴哖A鍧囦笅闄嶏紝鑲濈値鎭㈠鏈烶A琛€娴嗘祿搴︾殑鎭㈠鏃╀簬ALB銆侾A缁撳悎杞皑閰躲€佽儐绾㈢礌妫€娴嬪涓嶅悓绫诲瀷鑲濊剰鐤剧梾鍜岄潪鑲濊剰鐤剧梾鏈夐壌鍒剰涔夛紝濡傚墠鐧借泲鐧姐€佽浆姘ㄩ叾銆佽儐绾㈢礌鍧囧楂橈紝澶氬睘鎬ユ€ц倽鑴忕柧鐥咃紝濡傚墠鐧借泲鐧戒笉澧為珮锛屼粎杞皑閰躲€佽儐绾㈢礌澧為珮鍒欏簲鑰冭檻闈炶倽鑴忔湰韬柧鐥呫€侟/li>
- l 璐熸€ф€ユ€ф椂鐩稿弽搴旇泲鐧斤細鍦ㄦ€ユ€х値鐥囥€佹參鎬ф劅鏌撱€佹伓鎬ц偪鐦ゃ€佸垱浼ょ瓑鎬ラ渶鍚堟垚铔嬬櫧璐ㄧ殑鎯呭喌涓嬶紝琛€娓匬A鍧囪繀閫熶笅闄岦span style="color:hsl(212,80%,42%);">[1]銆侟/li>
- l PA娴撳害澧為珮锛氬墠鐧借泲鐧藉彲閫氳繃鑲捐剰鎺掓硠锛岃偩鍔熻兘涓嶅叏鏃跺叾鎺掓硠鍑忓皯锛屽鑷磋涓墠鐧借泲鐧芥按骞冲崌楂樸€傚洜姝わ紝鍦ㄨ瘎浼拌偩鍔熻兘鏃讹紝闇€缁撳悎鍏朵粬鎸囨爣缁煎悎鍒嗘瀽銆侾A娴撳害澧為珮杩樺彲瑙佷簬闇嶅閲戠梾[1]銆佹姉鐐庤嵂鐗╂不鐤楀拰鍙ｆ湇閬垮瓡鑽€侟/li>
- l 鏈夎崯钀冪爺绌跺緱鍑虹粨璁猴細浣庣櫧铔嬬櫧-绾ょ淮铔嬬櫧鍘熸瘮(AFR)鍜岄珮绾ょ淮铔嬬櫧鍘?鍓嶇櫧铔嬬櫧姣?FPR)涓庣檶鐥囨浜＄巼鍜屽鍙戦闄╃殑澧炲姞鐩稿叧銆侫FR鍜孎PR鍙兘鏄緢鏈夊墠閫旂殑鐧岀棁棰勫悗鏍囧織鐗?span style="color:hsl(212,80%,42%);">[7]銆侟/li>
閫傜敤绉戝
|
閫傜敤绉戝 |
閫傛浜虹兢 |
|
鑲濊儐鍐呯/鑲濈梾绉慄/strong> |
鑲濊剰鐤剧梾鎮ｈ€咃紙鍖呮嫭鑲濈値銆佽倽纭寲銆佽倽鐧岀瓑锛堻/p> |
|
鍐呯/鑲惧唴绉慄/strong> |
鑲惧姛鑳戒笉鍏ㄦ偅鑰呫€佺硸灏跨梾銆侀珮琛€鍘嬬瓑 |
|
鎰熸煋绉?ICU/鎬ヨ瘖绉慄/strong> |
鍙戠儳銆佹劅鏌撱€佽創姣掔棁銆佸垱浼ゃ€佹墜鏈瓑 |
|
钀ュ吇绉?鑰佸勾绉慄/strong> |
鎱㈡€х柧鐥呫€佹秷鍖栭亾鐤剧梾銆佽€佸勾浜虹瓑 |
|
濡囦骇绉慄/strong> |
瀛曞 |
|
鍎跨 |
钀ュ吇涓嶈壇 |
|
鑲跨槫绉慄/strong> |
鑲跨槫鎮ｈ€匋/p> |
|
浣撴绉?浣撴涓績 |
鏅€氫綋妫€浜虹兢 |
鍙傝€冩枃鐚?/h3>
[1] 灏氱孩, 鐜嬫瘬涓? 鐢冲瓙鐟? 鍏ㄥ浗涓村簥妫€楠屾搷浣滆绋媅M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[2] 灏逛竴鍏? 鍊煿鍗? 涓村簥鐢熺墿鍖栧妫€楠屾妧鏈痆M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[3] 姊佹鐝?姊佸钀?鏈卞垰. 鐗圭铔嬬櫧妫€娴嬪湪鍗遍噸鐥呬汉搴旂敤鑲犲唴钀ュ吇鏀寔涓殑涓村簥鎰忎箟[J]. 鍥介檯鍖昏嵂鍗敓瀵兼姤,2007,13(11):44-46.
[4] 涓浗鍖诲笀鍗忎細鑲捐剰鍐呯鍖诲笀鍒嗕細,涓浗涓タ鍖荤粨鍚堝浼氳偩鑴忕柧鐥呬笓涓氬鍛樹細钀ュ吇娌荤枟鎸囧崡涓撳鍗忎綔缁? 涓浗鎱㈡€ц偩鑴忕梾钀ュ吇娌荤枟涓村簥瀹炶返鎸囧崡(2021鐗?[J]. 涓崕鍖诲鏉傚織,2021,101(8):539-559.
[5] Keller U. Nutritional Laboratory Markers in Malnutrition. J Clin Med. 2019 May 31;8(6):775.
[6] Yasmin MY, Aziz B, Nazim M, Madhavan RK. Prealbumin rather than albumin is a more sensitive indicator of acute liver disease. Malays J Pathol. 1993 Dec;15(2):147-50.
[7] Sun DW, An L, Lv GY. Albumin-fibrinogen ratio and fibrinogen-prealbumin ratio as promising prognostic markers for cancers: an updated meta-analysis. World J Surg Oncol. 2020 Jan 13;18(1):9.
鎸囧崡鍏辫瘑
