AMG-α1-寰悆铔嬬櫧娴嬪畾璇曞墏鐩?鑳朵钩鍏嶇柅姣旀祳娉?
--鏃╂湡鑲惧姛鑳芥崯浼ゆ娴嬫寚鏍囷紝鑲惧皬绠℃崯浼ゆ爣蹇楃墿
鏍锋湰绫诲瀷锛氭柊椴滆娓呮垨灏挎恫
閫傜敤浠櫒锛氭湰璇曞墏鐩掗€傜敤浜庣粷澶у鏁颁富娴佺敓鍖栧垎鏋愪华
璇曞墏鐩掍紭鍔军/h4>
1.琛€灏垮悓妫€锛屾弧瓒充复搴婃娴嬮渶姹侟/p>
2.閲囩敤鑳朵钩鍏嶇柅姣旀祳娉曪紝鎻愰珮鐏垫晱搴﹀拰鐗瑰紓鎬?/p>
鎸囨爣绠€浠婞/h3>
α1-寰悆铔嬬櫧锛?alpha;1-Microglobulin锛孉MG锛夋槸涓€绉嶇敱鑲濊剰鍜屾穻宸寸粏鑳炲悎鎴愮殑浣庡垎瀛愰噺绯栬泲鐧斤紝骞挎硾瀛樺湪浜庝汉浣撳悇绉嶄綋娑插強娣嬪反缁嗚優鑶滆〃闈紝鍏锋湁杩樺師閰躲€佽绾㈢礌鍜岃嚜鐢卞熀缁撳悎娲绘€э紝鏈夊姪浜庝繚鎶ょ粏鑳炪€佸櫒瀹樺厤鍙楁哀鍖栧簲婵€鐩稿叧鐤剧梾鐨勬崯瀹崇瓑鍔熻兘銆傚叾鍒嗗瓙閲忕害涓?3000閬撳皵椤匡紝鐢?67涓皑鍩洪吀缁勬垚銆侫MG鐨勪骇鐢熼噺鎭掑畾锛屽翱涓殑鎺掑嚭閲忚緝灏戝彈鑲惧鍥犵礌鐨勫奖鍝嶃€傝繎骞存潵锛孉MG鐨勬娴嬪湪涓村簥涓婄殑搴旂敤瓒婃潵瓒婂箍娉涳紝涓昏鏄敤浣滆偩鑴忕柧鐥呯殑鏃╂湡璇婃柇鍙婇潪鐗瑰紓鎬ц偪鐦ゆ爣蹇楃墿銆侟/p>
妫€娴嬪師鐞咟/h3>
鏈瘯鍓備互鑳朵钩鍏嶇柅姣旀祳娉曚綔涓烘祴瀹氬師鐞嗐€傝瘯鍓傜洅涓殑α1-寰悆铔嬬櫧鎶椾綋涓庢牱鏈腑鐨?alpha;1-寰悆铔嬬櫧鎶楀師缁撳悎鍙戠敓鍙嶅簲锛屽舰鎴愬厤鐤鍚堢墿銆傚湪娉㈤暱600nm澶勬娴嬪叾娴婂害鍙樺寲锛屽叾鍙樺寲绋嬪害涓庢牱鏈腑鐨?alpha;1-寰悆铔嬬櫧鍚噺鎴愭姣斻€侟/p>
涓村簥搴旂敤
- AMG浣滀负鑲炬崯浼ょ殑鏃╂湡鎸囨爣锛氳偩灏忕悆婊よ繃鍔熻兘鍙楁崯锛岃偩灏忕閲嶅惛鏀跺拰浠ｈ阿鑳藉姏闄嶄綆銆佹穻宸寸粏鑳炴縺娲绘垨鐮村潖閲婃斁锛屽潎浣緼MG钃勭Н鍜屽楂樸€侫MG杈?beta;2-MG鏇存槗鍙楀埌鑲惧皬鐞冩护杩囪啘鐨勫奖鍝嶏紝褰撹偩鐥呮棭鏈燂紝鑲惧皬鐞冨彂鐢熻交寰敼鍙樻椂锛岃娓匒MG灏变細鏈夋樉钁楁敼鍙橈紝鐢辨璁や负AMG鍦ㄥ弽鏄犺偩灏忕悆婊よ繃鍔熻兘鏂归潰姣?beta;2-MG鏇翠负鐏垫晱鍜岀壒寮傦紝AMG鍦ㄦ棭鏈熻瘖鏂偩鑴忓師鍙戠柧鐥呮柟闈㈡樉鏈変紭鍔军span style="color:hsl(212,80%,42%);">[1]銆傜敱浜庡翱娑睞MG涓嶅彈灏挎恫pH鍊肩殑褰卞搷锛屽洜姝よ緝灏挎恫涓叾浠栧井鐞冭泲鐧界殑娴嬪畾鏇翠负绮剧‘銆佺ǔ瀹氥€傛湁瀛﹁€呭彂鐜帮紝鑲惧皬绠″潖姝绘偅鑰呯殑灏緼MG娴嬪畾鍊煎崌楂橈紝涓斾笌鐥呮儏涓ラ噸绋嬪害鍛堟鐩稿叧锛孉MG閫傚悎浣滀负鍒ゆ柇浣曟椂杩涜閫忔瀽娌荤枟浠ュ強娌荤枟鍚庣殑鑲惧姛鑳界洃娴婞span style="color:hsl(212,80%,42%);">[2]銆傛甯告儏鍐典笅锛孉MG鑳借嚜鐢遍€氳繃鑲惧皬鐞冩护杩囪啘锛岀粷澶ч儴鍒嗚鑲捐繎鏇插皬绠￠噸鍚告敹锛屾晠姝ｅ父灏夸腑AMG鍚噺鐢氬井锛屽綋杩戞洸灏忕鍙楁崯鏃讹紝閲嶅惛鏀跺噺灏戯紝灏夸腑AMG鎺掓硠閲忔槑鏄惧鍔狅紝鏁呭翱AMG鏄弽鏄犺繎绔偩灏忕杞诲井鎹熷鐨勬晱鎰熸寚鏍囥€侟/li>
- AMG涓庣硸灏跨梾鑲剧梾锛氱硸灏跨梾鑲剧梾(DKD)鏄硸灏跨梾(DM)鏈€甯歌鍜屾渶涓ラ噸鐨勫苟鍙戠棁涔嬩竴銆侶ong绛堻span style="color:hsl(212,80%,42%);">[3]鐮旂┒鍙戠幇锛屽翱AMG姘村钩涓嶥M鐨勭梾绋嬨€佷弗閲嶇▼搴﹀強琛€绯栫殑鎺у埗鏈夌洿鎺ュ叧绯汇€侫MG妫€娴嬪彲浠ュ湪閮ㄥ垎鎮ｈ€呭翱铔嬬櫧澶勪簬姝ｅ父鍊兼椂鍙戠幇DM鐨勮偩鑴忔崯瀹筹紝杈惧埌鏃╂湡娌荤枟锛岄樆姝㈢柧鐥呯殑杩涘睍銆傘€婁腑鍥芥垚浜虹硸灏跨梾鑲捐剰鐥呬复搴婅瘖鏂殑涓撳鍏辫瘑2015銆婞span style="color:hsl(212,80%,42%);">[4]鎺ㄨ崘瀵笹3a~5A1鏈烡KD鎮ｈ€咃紝鍗冲翱鐧借泲鐧介槾鎬х殑DKD鎮ｈ€咃紝杩涜鑲惧皬绠″彈绱殑绛涙煡锛岀瓫鏌ユ寚鏍囨帹鑽愰噰鐢ㄤ换鎰忔椂鐐?娓呮櫒棣栨灏挎渶浣?灏挎爣鏈祴瀹欰MG銆傘€婄硸灏跨梾鑲捐剰鐤剧梾鏃╂湡棰勬祴涓庤瘖鏂笓瀹跺叡璇?021銆婞span style="color:hsl(212,80%,42%);">[5]鎸囧嚭锛屽湪绯栧翱鐥呰偩鐥?DKD)鏃╂湡锛岃偩灏忕鎹熶激鏍囧織鐗╋紝姣斿α1-寰悆铔嬬櫧(AMG)銆?beta;2-寰悆铔嬬櫧(β2-MG)銆佽儽鎶戠礌C鍜岃榛勯唶缁撳悎铔嬬櫧(RBP)绛夊湪灏挎恫涓惈閲忓崌楂橈紝鎻愮ず鑲惧皬绠℃崯浼や笌DKD鍙戠梾鏈夊叧銆侟/li>
- 鑲濈Щ妞嶆湳鍚庤偩鍔熻兘鎹熷璇勪环锛氶挋璋冪７閰搁叾鎶戝埗鍓傛槸鑲濈Щ妞嶆偅鑰呭父鐢ㄧ殑鎶楁帓寮傝嵂鐗╋紝鐮旂┒琛ㄦ槑锛孉MG鍙敤浜庢娴嬮挋璋冪７閰搁叾鎶戝埗鍓?CNI)鐩稿叧鑲炬瘨鎬э紝鍙綔涓篊NI寮曡捣鐨勮偩姣掓€х殑鏃╂湡鍜屾晱鎰熺殑鎸囨爣[6]銆侟/li>
- 鍏朵粬搴旂敤锛氶噾灞炰腑姣掑彲瀵艰嚧涓嶅彲閫嗙殑鎱㈡€ц偩鍔熻兘鎹熷锛孞ung绛堻span style="color:hsl(212,80%,42%);">[7] 鍙 Zhao绛堻span style="color:hsl(212,80%,42%);">[8] 鐨勭爺绌惰〃鏄庯紝AMG鏄娴嬬敱闀夊強姹炲紩璧风殑鏃╂湡鑲炬崯瀹崇殑鏁忔劅鎸囨爣銆傚惔鍏堝钩绛堻span style="color:hsl(212,80%,42%);">[9]鎶ラ亾锛屾隘璇烘様搴风殑搴旂敤鍙互瀵艰嚧灏緼MG鍗囬珮锛岃鏄庢隘璇烘様搴峰鑲惧皬绠℃湁鎹熷浣滅敤锛岀敱姝ゆ彁绀轰复搴婂尰鐢熷湪鍦ㄨ繍鐢ㄦ椂搴旇€冭檻鍏跺畨鍏ㄦ€э紝鐗瑰埆瀵逛簬宸茬粡鏈夎偩鍔熻兘鎹熷鐨勬偅鑰咃紝鏇村簲璇ュ紩璧疯鎯曘€侟/li>
閫傜敤绉戝
|
閫傜敤绉戝 |
搴旂敤 |
|
鑲惧唴绉慄/strong> |
鑲惧姛鑳戒笉鍏紝濡傝偩灏忕悆鎹熶激鏃╂湡銆佸師鍙戞€ц偩灏忕悆鑲剧値銆侀棿璐ㄦ€ц偩鐐庛€佺硸灏跨梾鑲剧梾銆佺嫾鐤偩銆佹€ユ參鎬ц偩鍔熻兘琛扮绛堻/p> |
|
鑲跨槫绉慄/strong> |
鑲濈檶绛堻/p> |
|
琛€娑茬 |
IgA鍨嬮楂撶槫 |
|
鍐呭垎娉岀 |
绯栧翱鐥呰偩鐥呮棭鏈熻瘖鏂腑锛屽翱AMG鏄弽搴旇偩灏忕閲嶅惛鏀跺姛鑳芥崯浼ょ殑鏁忔劅鎸囨爣 |
鍙傝€冩枃鐚?/h3>
[1] 鍚夌敯鍜屾竻銆?alpha;-寰悆铔嬬櫧鍦ㄤ复搴婃楠屼腑鐨勫簲鐢?鍥藉鍖诲涓村簥鐢熺墿鍖栧涓庢楠屽鍒嗗唽锛?990,11(4):35.
[2] Herget S, Poppen D, Husing J, et al. Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis[J]. Clin Chem,2004, 50(3) : 552-558.
[3] Hong C, Hughes K, Chia K, et al. Urinary alphal-microglobulin as a marker of nephropathy in type 2 diabetic Asian subjects in Singapore[J]. Diabetes Care, 2003,26(2) : 338-342.
[4] 涓崕鍖诲浼氬唴鍒嗘硨瀛﹀垎浼? 涓浗鎴愪汉绯栧翱鐥呰偩鑴忕梾涓村簥璇婃柇鐨勪笓瀹跺叡璇哰J]. 涓崕鍐呭垎娉屼唬璋㈡潅蹇?2015,31(5):379-385.
[5] 寮犱繆娓?鑻忕櫧娴?寮犳嵎,绛? 绯栧翱鐥呰偩鑴忕柧鐥呮棭鏈熼娴嬩笌璇婃柇涓撳鍏辫瘑[J]. 涓崕鍐呯鏉傚織,2021,60(6):522-532.
[6] Li J, Liu B, Yan LN, et al. Microproteinuria for detecting calci-neurin inhibitor-related nephrotoxicity after liver transplantation[J]. World J Gastroenterol, 2009,15(23) : 2913-2917.
[7] Jung K,Pergande M,Graubaum H,et al. Urinary proteins and en-zymes as early indicators of renal dysfunction in chronic exposure to cadmium[J]. Clin Chem,1993,39(5) : 757-765.
[8] Zhao LQ, Shen J, You QC,et al. Screen of early indicators for re-nal damage in mercury workers[JJ. Sichuan Da Xue Xue Bao Yi Xue Ban,2008,39(3) : 461-463.
[9] 鍚村厛骞筹紝榛戝瓙娓咃紝闄堢瀛︼紝绛夈€傛隘璇烘様搴烽潤鑴夋寔缁緭娉ㄩ晣鐥涘灏?alpha;l-寰悆铔嬬櫧鐨勫奖鍝峓J].涓浗鏂拌嵂涓庝复搴婃潅蹇楋紝2005,24(11)锛?69-872.
鎸囧崡鍏辫瘑
