LDL-C-浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囨祴瀹氳瘯鍓傜洅(鐩存帴娉?琛ㄩ潰娲绘€у墏娓呴櫎娉?
--鍒ゅ埆楂樿剛琛€鐥囥€佸姩鑴夌播鏍风‖鍖栥€佸啝蹇冪梾銆侀珮琛€鍘嬬棁鍙戠敓鍗遍櫓绋嬪害鐨勯噸瑕佹寚鏍嘃/h3>
鏍锋湰绫诲瀷锛氳娓呮垨鑲濈礌閿?鏋告┘閰搁挔鎶楀嚌琛€娴咟/p>
閫傜敤浠櫒锛氭湰璇曞墏鐩掗€傜敤浜庣粷澶у鏁颁富娴佺敓鍖栧垎鏋愪华
璇曞墏鐩掍紭鍔军/h4>
1.閲囩敤鐩存帴娉?琛ㄩ潰娲绘€у墏娓呴櫎娉曪紝鐗瑰紓鎬ч珮锛屾姉骞叉壈鍔涘己
2.绮惧瘑搴﹂珮锛孋V≤3%
3.鏍″噯鍝佸畾鍊兼函婧愯嚦GBW09178
鎸囨爣绠€浠婞/h3>
鑴傝川瀵逛簬缁存寔鏈轰綋姝ｅ父鐢熺悊娲诲姩锛岀壒鍒槸鍦ㄨ兘閲忎唬璋㈠拰鑶滄瀯鎴愪腑鍏锋湁閲嶈鎰忎箟銆傝鑴傛槸琛€娑蹭腑鑴傜被鐗╄川鐨勬€荤О锛屽寘鎷儐鍥洪唶銆佺敇娌逛笁閰紙TG锛夊拰绫昏剛锛堝纾疯剛锛夌瓑銆傝鑴備笉婧朵簬姘达紝蹇呴』涓庣壒娈婄殑铔嬬櫧璐紝鍗宠浇鑴傝泲鐧斤紙apoprotein锛孉po锛夛紝缁撳悎褰㈡垚鑴傝泲鐧芥墠鑳芥憾浜庤娑诧紝琚繍杈撹嚦缁勭粐杩涜浠ｈ阿銆傛牴鎹矑寰勫ぇ灏忓拰姘村悎瀵嗗害涓嶅悓锛岃剛铔嬬櫧锛堢矑寰勯€愭笎鍙樺皬锛屾按鍚堝瘑搴﹂€愭笎鍙樺ぇ锛夊垎涓轰钩绯滃井绮掞紙CM锛夈€佹瀬浣庡瘑搴﹁剛铔嬬櫧锛圴LDL锛夈€佷腑闂村瘑搴﹁剛铔嬬櫧锛圛DL锛夈€佷綆瀵嗗害鑴傝泲鐧斤紙LDL 锛夊拰楂樺瘑搴﹁剛铔嬬櫧HDL銆傛澶栵紝杩樻湁涓€绉嶇壒娈婅剛铔嬬櫧绉颁负鑴傝泲鐧絘锛圠p(a)锛堻span style="color:hsl(212,80%,42%);">[1]銆傝娓呬綆瀵嗗害鑴傝泲鐧戒腑鑳嗗浐閱囧惈閲忔渶楂橈紝浣庡瘑搴﹁剛铔嬬櫧 (LDL) 鐢辨瀬浣庡瘑搴﹁剛铔嬬櫧 (VLDL) 杞寲鑰屾潵锛孡DL棰楃矑涓惈鑳嗗浐閱囬叝40%銆佹父绂昏儐鍥洪唶10%銆乀G 6%銆佺７鑴?0%銆佽泲鐧借川24%锛屾槸琛€娑蹭腑鑳嗗浐閱囧惈閲忔渶澶氱殑鑴傝泲鐧斤紝鏁呯О涓哄瘜鍚儐鍥洪唶鐨勮剛铔嬬櫧銆傚洜LDL棰楃矑涓儐鍥洪唶鍗犳瘮绾︿负50%锛屼綆瀵嗗害鑴傝泲鐧借儐鍥洪唶锛圠DL-C锛夋祿搴﹀熀鏈兘鍙嶆槧琛€娑睱DL棰楃矑姘村钩銆侺DL鐨勪富瑕佸姛鑳芥槸灏嗚倽鑴忓悎鎴愮殑鍐呮簮鎬ц儐鍥洪唶杞繍鑷宠倽澶栫粍缁囥€侺DL-C姘村钩鍗囬珮鏄嫭绔嬬殑鑷村姩鑴夌播鏍风‖鍖栧嵄闄╁洜绱犮€侟/p>
妫€娴嬪師鐞咟/h3>
鍙嶅簲鍒嗕袱姝ヨ繘琛岋細
绗竴姝ワ細R1涓仛闃寸瀛愪笌LDL褰㈡垚澶嶅悎鐗╋紝鍦ㄨ〃闈㈡椿鎬у墏1浣滅敤涓嬶紝涓嶄笌鑳嗗浐閱囬叾璇曞墏鍙嶅簲銆傝€屽叾瀹冭剛铔嬬櫧锛圕M锛孷LDL-C锛孒DL-C锛夊垯琚叾璇曞墏姘磋В浜х敓 H2O2锛屽湪缂轰箯鍋惰仈鍓傛椂琚秷鑰楄€屼笉鏄捐壊銆侟br />
绗簩姝ワ細R2涓〃闈㈡椿鎬у墏2浣縇DL閲婃斁CHO锛屽湪閰惰瘯鍓備笌鍋惰仈鍓備綔鐢ㄤ笅鐢熸垚绱壊鍖栧悎鐗╋紝鏈€澶у厜鍚告敹鍦?50nm宸﹀彸锛屽惛鍏夊害涓庢爣鏈腑浣庡瘑搴﹁剛铔嬬櫧鑳嗗浐閱囨祿搴︽垚姝ｆ瘮銆侟/p>
涓村簥搴旂敤
- LDL-C鍗囬珮鍙浜庡鏃忔€ч珮鑳嗗浐閱囪鐥?familial hypercholesterolemia锛孎H)(TC澧為珮锛孡DL-C澧為珮锛屼即鏈塇DL-C鍑忎綆)銆佸鏃忔€poB缂洪櫡鐥囥€佹贩鍚堝瀷楂樿剛琛€鐥囥€佲叀a鍨嬮珮鑴傝泲鐧借鐥?TC澧為珮锛孡DL-C澧為珮锛孴G姝ｅ父鎴栬交搴﹀楂?銆佺敳鐘惰吅鍔熻兘浣庝笅銆佹€ユ€у績鑲屾姝汇€佸啝蹇冪梾銆佽偩鐥呯患鍚堝緛鍜岀硸灏跨梾绛夛紝涔熷彲瑙佷簬绁炵粡鍘岄鍙婂瓡濡囥€侟/li>
- LDL-C鍗囬珮鏄姩鑴夌播鏍风‖鍖?atherosclerosis锛孉S)鐨勪富瑕佸嵄闄╁洜绱狅紝鍦ˋSCVD鑷寸梾涓捣鐫€鏍稿績浣滅敤銆傛彁鍊′互闄嶄綆琛€娓匧DL-C姘村钩鏉ラ槻鎺SCVD锛屼篃鏄洰鍓嶅浗鍐呭琛€鑴傚紓甯搁槻娌绘寚鍗楁帹鑽愮殑璋冭剛娌荤枟棣栬骞查闈剁偣[1]銆侟/li>
- LDL-C闄嶄綆鍙浜庡鏃忔€ф棤β鎴栦綆β鑴傝泲鐧借鐥囥€佽惀鍏讳笉鑹€佹參鎬ц传琛€銆佺敳鐘惰吅鍔熻兘浜㈣繘銆佹秷鍖栧惛鏀朵笉鑹€佽倽纭寲銆佹參鎬ф秷鑰楁€х柧鐥呫€佹伓鎬ц偪鐦ゃ€佸垱浼ゅ拰涓ラ噸鑲濈梾绛堻span style="color:hsl(212,80%,42%);">[2, 3]銆侟/li>
閫傜敤绉戝
|
閫傜敤绉戝 |
閫傛浜虹兢 |
|
鍐呯/蹇冨唴绉慄/strong> |
锛?锛夋湁 ASCVD 鐥呭彶鑰呫€傦紙2锛夊瓨鍦ㄥ椤 ASCVD 鍗遍櫓鍥犵礌锛堝楂樿鍘嬨€佺硸灏跨梾銆佽偉鑳栥€佸惛鐑 锛夌殑浜虹兢銆傦紙3锛夋湁鏃╁彂 CVD 瀹舵棌鍙茶€咃紙鎸囩敺鎬т竴绾х洿绯讳翰灞炲湪 55 宀佸墠鎴栧コ鎬т竴绾х洿绯讳翰灞炲湪65 宀佸墠鎮 ASCVD锛夛紝鎴栨湁瀹舵棌鎬ч珮鑴傝鐥囨偅鑰呫€佸鏃忔€ф棤β鎴栦綆β鑴傝泲鐧借鐥囨偅鑰呫€侟/p> |
|
鑲剧梾绉?鑲惧唴绉慄/strong> |
鑲剧梾缁煎悎寰?/p> |
|
鐨偆绉慄/strong> |
鐨偆鎴栬倢鑵遍粍鑹茬槫鍙婅窡鑵卞鍘氳€匋/p> |
|
娑堝寲绉?鑲濊儐鍐呯 |
娑堝寲鍚告敹涓嶈壇銆佽倽纭寲銆佷弗閲嶈倽鐥呯瓑 |
|
鍐呭垎娉岀 |
鐢茬姸鑵哄姛鑳藉紓甯伏/p> |
|
濡囦骇绉慄/strong> |
瀛曞 |
|
鑲跨槫绉慄/strong> |
鎭舵€ц偪鐦わ紝鎱㈡€ф秷鑰楁€х柧鐥匋/p> |
|
钀ュ吇绉慄/strong> |
钀ュ吇涓嶈壇 |
|
琛€娑茬 |
鎱㈡€ц传琛€ |
|
浣撴绉?浣撴涓績 |
鏅€氫綋妫€浜虹兢 |
鍙傝€冩枃鐚?/h3>
[1] 涓浗琛€鑴傜鐞嗘寚鍗椾慨璁㈣仈鍚堜笓瀹跺鍛樹細. 涓浗琛€鑴傜鐞嗘寚鍗?2023骞?[J]. 涓崕蹇冭绠＄梾鏉傚織,2023,51(3):221-255.
[2] 灏氱孩, 鐜嬫瘬涓? 鐢冲瓙鐟? 鍏ㄥ浗涓村簥妫€楠屾搷浣滆绋媅M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[3] 涓崕鍖诲浼氭楠屽尰瀛﹀垎浼?涓浗鍖诲笀鍗忎細妫€楠屽尰甯堝垎浼?涓浗鐢熺墿鍖栧涓庡垎瀛愮敓鐗╁浼氳剛璐ㄤ笌鑴傝泲鐧戒笓涓氬鍛樹細,绛? 涓浗涓村簥琛€鑴傛娴嬫寚鍗梉J]. 涓崕妫€楠屽尰瀛︽潅蹇?2022,45(10):1017-1033.
鎸囧崡鍏辫瘑
