寮虹洿鎬ц剨鏌辩値HLA-B27妫€娴嬭瘯鍓傜洅(娴佸紡缁嗚優浠硶)
--寮虹洿鎬ц剨鏌辩値閲嶈绛涙煡鍙婅緟鍔╄瘖鏂寚鏍嘃/h3>
鏍锋湰绫诲瀷锛欵DTA鎶楀嚌琛€
鏍″噯鍝侊細璇锋牴鎹墍鐢ㄦ祦寮忕粏鑳炰华鍨嬪彿閫夌敤鍘傚瑕佹眰閰嶅鐨勬牎鍑嗗搧
璐ㄦ帶鍝侊細璇锋牴鎹墍鐢ㄦ祦寮忕粏鑳炰华鍨嬪彿閫夌敤鍘傚鎺ㄨ崘鐨勮川鎺у搧
閰嶅浠櫒锛氫腑鐢烞ioCyte銆丗lowCyte/ZS-AE7S銆丗ACSCantoII銆丗ACSCalibur銆丏xFLEX銆丯avios銆丯ovoCyte銆丅riCyte E6绛夋祦寮忕粏鑳炰华
鎸囨爣绠€浠婞/h3>
HLA鏄汉绫讳富瑕佺粍缁囩浉瀹规€у鍚堜綋MHC)鐨勮〃杈句骇鐗╋紝鍦ㄥ厤鐤郴缁熶腑涓昏璐熻矗缁嗚優涔嬮棿鐨勭浉浜掕瘑鍒拰璇卞鍏嶇柅鍙嶅簲锛岃皟鑺傚厤鐤簲绛旂殑鍔熻兘銆侶LA-B27鎶楀師灞炰簬I鍨婱HC,鍩烘湰涓婅〃杈惧湪鏈轰綋鎵€鏈夋湁鏍哥粏鑳炰笂锛屽挨鍏舵槸娣嬪反缁嗚優琛ㄩ潰鍚噺涓板瘜銆侶LAB7涓嶩LA-B27鍚屽睘浜嶩LA-B7浜ゅ弶鍙嶅簲缇ゃ€侶LA-B7涓嶩LA-B27鍚屽睘浜嶩LA-B鐨処绫绘姉鍘燂紝瀛樺湪浜庢墍鏈夋湁鏍哥粏鑳炶〃闈紝鍖呮嫭琛€灏忔澘鍜岀綉缁囩孩缁嗚優銆侶LA-B27鍩哄洜涓庡己鐩存€ц剨鏌辩値鐨勫彂鐥呭瘑鍒囩浉鍏炽€侶LA-B27鏄竴绉嶄汉绫荤櫧缁嗚優鎶楀師锛屽畠鍦ㄥ厤鐤郴缁熶腑璧风潃閲嶈鐨勪綔鐢ㄣ€傛惡甯LA-B27鍩哄洜鐨勪汉鏇村鏄撴偅涓婂己鐩存€ц剨鏌辩値锛屼絾骞堕潪鎵€鏈夋惡甯﹁鍩哄洜鐨勪汉閮戒細鍙戠梾銆侶LA B27鏄己鐩存€ц剨鏌辩値妫€鏌ユ渶甯哥敤鐨勬娴嬫寚鏍囥€侟/p>
妫€娴嬪師鐞咟/h3>
娴佸紡缁嗚優浠硶锛氬緟娴嬫牱鏈殑缁嗚優鎮恫锛屽湪闉樻恫鐨勫寘鍥村拰绾︽潫涓嬶紝缁嗚優鎺掓垚鍗曞垪楂橀€熺敱娴佸姩瀹ゅ柗鍢村柗鍑猴紝褰㈡垚缁嗚優娑叉煴銆傚綋娑叉煴閫氳繃妫€娴嬪尯锛屽湪鍏ュ皠鐨勬縺鍏夋潫鐓у皠涓嬩骇鐢熷墠鍚戣鏁ｅ皠鍏夛紙FSC锛夊拰渚у悜瑙掓暎灏勫厜锛圫SC锛夛紝瀹冧滑鍒嗗埆鍙嶆槧缁嗚優澶у皬鍜岄绮掑害锛屾牴鎹繖浜涚壒鎬у彲浠ュ皢缁嗚優鍒嗙被銆傜粡涓€绉嶆垨鍑犵鐗规畩鑽у厜鏍囪鐨勬牱鏈紝鍦ㄦ縺鍏夋潫鐨勬縺鍙戜笅鎵€浜х敓鐨勭壒瀹氳崸鍏夛紝鍙鍏夊绯荤粺妫€娴嬪苟杈撻€佸埌璁＄畻鏈鸿繘琛屽垎鏋愶紝寰楀埌缁嗚優鐩稿簲鐨勫悇绉嶇壒鎬с€侟/p>
涓村簥搴旂敤
- 鏃╂湡璇婃柇SpA锛 HLA-B27妫€娴嬪湪鍚勭被缁撳悎鑴婃煴鍏宠妭鐐嶴pA涓兘鏈変竴瀹氱殑闃虫€х巼锛屼粠70-90%鍒?0-50%涓嶇瓑銆侟/li>
- 寮虹洿鎬ц剨鏌辩値AS璇婃柇锛氭垜鍥?0%AS鎮ｈ€匟LA-B27闃虫€э紝浣咹LA-B27闃存€ц€呭彧瑕佷复搴婅〃鐜板拰褰卞儚瀛︽鏌ョ鍚 AS鍒嗙被鏍囧噯锛屼害涓嶈兘鎺掗櫎AS鍙兘[1]銆傚浜庤叞鑳岀棝3涓湀浠ヤ笂銆佸彂鐥呭勾榫?lt;45宀佺殑鎮ｈ€咃紝HLA-B27妫€娴嬭兘绛涙煡鍑篈S鐨勬晱鎰熸€т负90%锛岃瘖鏂环鍊煎湪鍚勫弬鏁颁腑涓嶮RI骞跺垪棣栦綅锛屼絾鏇村叿鏈夋垚鏈紭鍔裤€?009骞村浗闄匒S璇勪及鍗忎細ASAS鍒跺畾鐨勪腑杞村瀷SpA鍒嗙被鏍囧噯[1]锛氳捣鐥呭勾榫?lt;45宀佸拰鑵拌儗鐥?gt;3涓湀鐨勬偅鑰咃紝鍔犱笂绗﹀悎涓嬭堪涓?椤规爣鍑嗭細(1)褰卞儚瀛︽彁绀洪楂傚叧鑺傜値锛屽姞涓?ge;1涓笅杩癝PA鐗瑰緛;(2)HLA-B27锛岄槼鎬э紝鍔犱笂≥2涓叾浠朣pA鐗瑰緛銆侟/li>
- 鍒ゆ柇鐥呮儏鐨勪弗閲嶇▼搴﹀拰棰勫悗锛 HLA-B27闃虫€ц€呮洿瀹规槗浼撮殢鎴栬繘灞曚负AS锛屼笖鏇村鏄撳嚭鐜扮郴缁熸€х梾鍙樺拰澶氫釜鍣ㄥ畼鐨勬崯瀹筹紝濡備富鍔ㄨ剦鐐庛€佷富鍔ㄨ剦鐡ｅ叧闂笉鍏ㄣ€佸績鑲屼紶瀵煎紓甯搞€佽偤涓婂彾绾ょ淮鍖栧拰IgA鑲剧梾绛夛紝搴斿敖鏃╅噰鍙栧共棰勬帾鏂姐€侟/li>
閫傜敤绉戝
楠ㄧ銆佸唴绉戙€侀婀垮厤鐤绛堻/p>
鍙傝€冩枃鐚?/h3>
[1] 榛勭兘锛屾湵鍓戯紝鐜嬬帀鍗?绛? 寮虹洿鎬ц剨鏌辩値璇婄枟瑙勮寖. 涓崕鍐呯鏉傚織锛?022锛?1(08):893-900.
[2] 涓崕鍖诲浼氶婀跨梾瀛﹀垎浼? 寮虹洿鎬ц剨鏌辩値璇婃柇鍙婃不鐤楁寚鍗梉J]. 涓崕椋庢箍鐥呭鏉傚織,2010,14(8):557-559.
[3] 璋㈤泤,鏉ㄥ厠铏?鍚曢潚,绛? 寮虹洿鎬ц剨鏌辩値/鑴婃煴鍏宠妭鐐庢偅鑰呭疄璺垫寚鍗梉J]. 涓崕鍐呯鏉傚織,2020,59(7):511-518.
鎸囧崡鍏辫瘑
|
搴忓彿 |
鎸囧崡/鍏辫瘑鍚嶇О |
瑕佺偣 |
|
1 |
寮虹洿鎬ц剨鏌辩値璇婃柇鍙婃不鐤楁寚鍗梉2] |
2009骞碅SAS鎺ㄨ崘鐨勪腑杞村瀷SpA鐨勫垎绫绘爣鍑嗭細璧风梾骞撮緞<45宀佸拰鑵拌儗鐥?ge;3涓湀鐨勬偅鑰咃紝鍔犱笂绗﹀悎涓嬭堪涓?绉嶆爣鍑嗭細鈶犲奖鍍忓鎻愮ず楠堕珎鍏宠妭鐐庡姞涓?ge;1涓笅杩扮殑SA鐗瑰緛锛汓strong>鈶LA-B27闃虫€у姞涓?ge;2涓笅杩扮殑鍏朵粬SPA鐗瑰緛銆侟/strong> |
|
2 |
寮虹洿鎬ц剨鏌辩値/鑴婃煴鍏宠妭鐐庢偅鑰呭疄璺垫寚鍗梉3] |
AS/SpA鏄笌閬椾紶瀵嗗垏鐩稿叧鐨勭柧鐥咃紝宸插彂鐜扮柧鐥呮槗鎰熷熀鍥犱箣涓€鏄疕LA-B27銆傚仴搴蜂汉缇や篃鏈変竴瀹氭瘮渚婬LA-B27闃虫€х巼锛屼笖瀛樺湪浜虹宸紓锛屼笘鐣岃寖鍥村唴鍋ュ悍浜虹兢HLA-B27闃虫€х巼鍦?%~25%锛屼絾AS/SpA鎮ｈ€匟LA-B27闃虫€х巼鏄捐憲楂樹簬鍋ュ悍浜虹兢銆侟br /> 浠匟LA-B27闃虫€т笉鑳戒綔涓哄垎绫昏瘖鏂瑼S/SpA鐨勫敮涓€璇佹嵁锛屼絾鍏堕槼鎬у閴村埆鍏朵粬鑴婃煴鍏宠妭鐤剧梾浜︽湁杈冨ぇ鍙傝€冧环鍊笺€侟/p> |
|
3 |
寮虹洿鎬ц剨娉ㄧ値璇婄枟瑙勮寖[1] |
铏界劧鎴戝浗AS鎮ｈ€匟LA-B27闃虫€х巼杈?0%宸﹀彸锛屼絾HLA-B27骞舵棤璇婃柇鐗瑰紓鎬с€傝€孒LA-B,闃存€ц€呭彧瑕佷复搴婅〃鐜板拰褰卞儚瀛︽鏌ョ鍚圓S鍒嗙被鏍囧噯锛屼害涓嶈兘鎺掗櫎AS鍙兘銆侟/p> |
鐩稿叧浜у搧
