AFU-α-L-宀╄椈绯栬嫹閰舵祴瀹氳瘯鍓傜洅(CNPF搴曠墿娉?

--鍘熷彂鎬ц倽鐧岀殑杈呭姪璇婃柇銆佹湳鍚庡鍙戝強鐤楁晥鐩戞祴锛屽弽鏄犺倽鑳嗙柧鐥呬弗閲嶇▼搴?/h3>

鏍锋湰绫诲瀷锛氳娓匋/p>

閫傜敤浠櫒锛氭湰璇曞墏鐩掗€傜敤浜庣粷澶у鏁颁富娴佺敓鍖栧垎鏋愪华

璇曞墏鐩掍紭鍔军/h4>

1.閲囩敤鏂板瀷搴曠墿閰舵硶娴嬪畾锛屾姉骞叉壈鑳藉姏寮猴紝妫€娴嬬伒鏁忓害楂楛/p>

2.绮惧瘑搴﹂珮锛孋V≤5%

3.绾挎€ц寖鍥村锛?锝?00 U/L

 

鎸囨爣绠€浠婞/h3>

α-L-宀╄椈绯栬嫹閰讹紙α-L-fucosidase锛孉FU锛夋槸涓€绉嶆憾閰朵綋閰告€ф按瑙i叾锛屽箍娉涘瓨鍦ㄤ簬浜轰綋鍚勭粍缁囥€佺粏鑳炴憾閰朵綋鍜屼綋娑蹭腑锛屾澶栵紝鑳庣洏銆佽儙鍎跨粍缁囥€佽剳銆佽偤銆佽倽銆佽儼銆佽偩浠ュ強琛€娓呫€佸翱娑层€佸斁娑插拰娉恫涓潎鍚湁 AFU銆侫FU鍙按瑙?alpha;-1,2锛?alpha;-1,3锛?alpha;-1,4 鍜?alpha;-1,6绯栬嫹閿紝鍏剁敓鐞嗗姛鑳芥槸鍙備笌鍚博钘荤硸鍩虹殑鍚勭绯栬剛銆佺硸铔嬬櫧銆佺矘澶氱硸绛夊ぇ鍒嗗瓙鐗╄川鐨勫垎瑙d唬璋↑span style="color:hsl(212,80%,42%);">[1]銆侟/p>

 

妫€娴嬪師鐞咟/h3>

鏍锋湰涓?alpha;-L-宀╄椈绯栬嫹閰讹紙AFU锛夊偓鍖?-姘?瀵圭鍩洪厷-α-L-宀╄椈鍚″杻绯栬嫹锛圕NPF锛夋按瑙g敓鎴?-姘?瀵圭鍩洪厷锛圕NP锛夛紝寮曡捣娉㈤暱405nm锛?00nm~420nm锛夊娴嬪畾鍚稿厜搴︾殑鍗囬珮锛屽惛鍏夊害鍗囬珮鐨勯€熺巼涓庢牱鏈腑AFU鐨勬椿鍔涙垚姝f瘮銆侟/p>

 

涓村簥搴旂敤

  • AFU鏄師鍙戞€ц倽鐧?PHC)鐨勮緟鍔╄瘖鏂€佹湳鍚庡鍙戝強鐤楁晥鐩戞祴鎸囨爣銆傚師鍙戞€ц倽鐧?PHC)鏄洰鍓嶆垜鍥界4浣嶅父瑙佹伓鎬ц偪鐦ゅ強绗?浣嶈偪鐦よ嚧姝荤梾鍥狅紝涓ラ噸濞佽儊浜虹被鍋ュ悍銆侾HC鐨勭梾鐞嗙被鍨嬩富瑕佸寘鎷倽缁嗚優鐧?HCC)銆佽倽鍐呰儐绠$檶(ICC)鍜屾贩鍚堝瀷鑲濈檶(HCG-ICC)锛屽叾涓璈CC鍗?5%~90%[2]銆侶CC鎮h€呰娓呬腑AFU姘村钩鏄庢樉楂樹簬鍋ュ悍浜虹兢鍜岃倽纭寲鎮h€咃紝鍏惰瘖鏂璈CC鐨勭伒鏁忓害涓 60.0锝?0.0%锛岀壒寮傚害涓 55.0锝?8.0%[3]銆侫FU瀵 AFP 闃存€х梾渚嬪強灏忕粏鑳 HCC 鏈夎緟鍔╄瘖鏂环鍊硷紝涓斿彲浣滀负HCC鏈悗澶嶅彂鍜岀枟鏁堢洃娴嬬殑鎸囨爣;AFU浣滀负鐙珛鐨勯鍚庨娴嬪洜瀛愶紝鎮h€呮湳鍓岮FU>35 U/L鐨勬偅鑰呮湳鍚庤倽鐧屾洿瀹规槗澶嶅彂[4]銆侫FU涓嶢FP鏃犳槑鏄剧浉鍏筹紝AFP銆丄FU 鑱斿悎鍙娇鍘熷彂鎬ц倽鐧?PHC)璇婃柇鐨勭壒寮傚害銆佺伒鏁忓害鎻愰珮锛屽埄浜庢棭鏈熺瓫鏌ワ紝鐗瑰埆鏄AFP闃存€у拰灏忕粏鑳炶倽鐧岀殑璇婃柇浠峰€兼洿澶?span style="color:hsl(212,80%,42%);">[5]銆侫FU娲绘€ч珮浣庝笌鑲濈檶鐨勫ぇ灏忎互鍙夾FP娴撳害鏃犳槑鏄剧浉鍏虫€с€備竴浜涜倽鐧屼綋绉緢灏忥紝浣咥FU娲绘€у緢楂楛span style="color:hsl(212,80%,42%);">[6]銆侟/li>
  • AFU鍦ㄥ叾浠栬倽鑳嗙柧鐥呯柧鐥呬腑鐨勫簲鐢ㄦ參鎬ц倽鐐庛€佽倽绾ょ淮鍖栧拰鑲濈‖鍖栨偅鑰匒FU浜﹀鍔燑span style="color:hsl(212,80%,42%);">[7]锛屼絾涓€鑸粎杞诲害鍗囬珮锛屼笖闅忕柧鐥呯殑娌绘剤鍜屽ソ杞€屼笅闄嶃€侟/li>
  • 宀╄椈绯栬嫹璐Н鐥囩殑璇婃柇鍜岄壌鍒瘖鏂€傞仐浼犳€FU缂轰箯鍙娇鍚博钘荤硸鍩虹殑浣庤仛绯栥€佺硸鑲界硸铔嬬櫧鍜岀硸鑻疯繖浜涚墿璐ㄤ粠鍒濈敓鍎胯捣灏卞湪缁勭粐涓爢绉紝寮曡捣宀╄椈绯栬嫹璐Н鐥呫€傛偅鑰呯粍缁囥€佸翱娑插強琛€娑蹭腑AFU娲诲姏缂轰箯鎴栭檷浣庯紝AFU娴嬪畾鍙崗鍔╄鐥呯殑璇婃柇锛屽苟鍊熶互涓庡叾浠栭仐浼犳€х矘澶氱硸璐Н鐥呴壌鍒紝杩欎篃鏄棭鏈熷AFU妫€娴嬬殑涓昏鐩殑[1, 8]銆侟/li>
  • AFU鐨勫叾浠栦复搴婂簲鐢ㄣ€傝娓匒FU闅忓濞犲懆鏁扮殑澧炲姞鑰屽鍔狅紝鍦ㄨ嚜鐒跺垎濞╁悗鎴栦汉寮忕粓姝㈠濞犲悗杩呴€熶笅闄岦span style="color:hsl(212,80%,42%);">[6, 7]銆傝娓匒FU鍚噺鍙綔涓哄濞犳櫄鏈熻儙鍎跨敓闀垮彂鑲层€佽儙鐩樻垚鐔熸儏鍐电殑鐩戞祴鎸囨爣[9-11]銆傚厛鍏嗘祦浜ф偅鑰呯殑琛€娓匒FU銆佸瓡閰€丅-HCG姘村钩鍧囨槑鏄捐緝浣庯紝鑱斿悎妫€娴嬩笁椤规寚鏍囧鍏堝厗娴佷骇鍏锋湁杈冨ソ鐨勮瘖鏂剰涔堻span style="color:hsl(212,80%,42%);">[12, 13]銆傝偤鐧屻€佷钩鑵虹檶銆佸瓙瀹檶鍙婄硸灏跨梾鎮h€呰娓匒FU姘村钩涔熶笉鍚岀▼搴︾殑鍗囬珮[5]銆傚翱AFU娴嬪畾鍙棭鏈熸晱鎰熷湴鍙嶆槧杩戠鑲惧皬绠℃崯瀹颤span style="color:hsl(212,80%,42%);">[14]銆侟/li>

 

閫傜敤绉戝

閫傜敤绉戝

閫傛浜虹兢

娑堝寲鍐呯/鑲濈梾绉?鑲濊儐澶栫

鍘熷彂鎬ц倽鐧岋紝鑲濈‖鍖栵紝鎬ユ€ц倽鐐庛€佹參鎬ц倽鐐嶞/p>

閬椾紶鐥呯

宀╄椈绯栬嫹璐Н鐥囨偅鑰匋/p>

濡囦骇绉慄/strong>

瀛曞锛屽厛鍏嗘祦浜ф偅鑰咃紝濡婂绯栧翱鐥呮偅鑰匋/p>

鑰佸勾绉?鍐呭垎娉岀

绯栧翱鐥呮偅鑰匋/p>

鑲惧唴绉慄/strong>

绯栧翱鐥呮偅鑰咃紝绯栧翱鐥呰偩鐥呮偅鑰匋/p>

蹇冨唴绉慄/strong>

楂樿鍘嬫偅鑰匋/p>

鑲虹梾绉?鍛煎惛鍐呯

鑲洪儴鐤剧梾鎮h€匋/p>

鑲跨槫绉慄/strong>

鑲虹檶銆佷钩鑵虹檶銆佸瓙瀹檶鎮h€匋/p>

 

鍙傝€冩枃鐚?/h3>

[1] 绾叏姹?瀛欎附涓? α-L-宀╄椈绯栬嫹閰舵娴嬬殑涓村簥搴旂敤[J]. 鍖诲妫€楠屼笌涓村簥,2008,19(4):79-80.
[2] 涓崕鍖诲浼氭楠屽尰瀛﹀垎浼氬垎瀛愯瘖鏂缁? 鑲濈粏鑳炵檶鐢熺墿鏍囧織鐗╂娴嬪強搴旂敤涓撳鍏辫瘑[J]. 鍥介檯妫€楠屽尰瀛︽潅蹇?2020,41(24):2945-2948.
[3] Waidely E, Al-Yuobi AR, Bashammakh AS, El-Shahawi MS, Leblanc RM. Serum protein biomarkers relevant to hepatocellular carcinoma and their detection. Analyst. 2016 Jan 7;141(1):36-44.
[4] Wang K, Guo W, Li N, Shi J, Zhang C, Lau WY, Wu M, Cheng S. Alpha-1-fucosidase as a prognostic indicator for hepatocellular carcinoma following hepatectomy: a large-scale, long-term study. Br J Cancer. 2014 Apr 2;110(7):1811-9.
[5] 涓ユ枃濞?鐢茶儙铔嬬櫧,a-L-宀╄椈绯栬嫹閰惰仈鍚堟娴嬪湪鏃╂湡璇婃柇鍘熷彂鎬ц倽鐧岀殑搴旂敤鐮旂┒[C]//绗竷灞婂叏鍥藉悍澶嶄笌涓村簥鑽瀛︽湳浜ゆ祦浼氳.鍖椾含甯傛湞闃冲尯妗撳叴鑲跨槫鍖婚櫌, 2024.
[6] 灏逛竴鍏? 鍊煿鍗? 涓村簥鐢熺墿鍖栧妫€楠屾妧鏈痆M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[7] 灏氱孩, 鐜嬫瘬涓? 鐢冲瓙鐟? 鍏ㄥ浗涓村簥妫€楠屾搷浣滆绋媅M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[8] 寮犵鏄? 鏉庡仴鏂? 榄忔槑绔? 绛? 鐜颁唬涓村簥鐢熷寲妫€楠屽[M]. 绗?鐗? 鍖椾含: 浜烘皯鍐涘尰鍑虹増绀? 2003.
[9] 椹簯鏋? 濡婂鍙婇潪濡婂濡囧コ琛€娓 L-宀╄椈绯栬嫹閰舵娴嬪垎鏋怺J]. 涓栫晫鏈€鏂板尰瀛︿俊鎭枃鎽?杩炵画鍨嬬數瀛愭湡鍒?,2016,16(22):133-133,136.
[10] 璐捐壋闇?浣曠帀娲?绋嬫櫙姘? 濡婂鏅氭湡瀛曞琛€娓卆-L-宀╄椈绯栬嫹閰舵椿鎬у彉鍖栧強鎰忎箟[J]. 鎶ょ悊鐮旂┒,2016,30(35):4461-4462.
[11] 鐜嬪┃濠?鐜嬫枃鐕?甯告案瓒? 鏅氭湡濡婂濡囧コ琛€娓?alpha;-L-宀╄椈绯栬嫹閰跺拰纰辨€х7閰搁叾妫€娴嬪強涓村簥鎰忎箟[J]. 涓浗鍖昏嵂绉戝,2011,1(20):181-182.
[12] 璧栫姊? 琛€娓匒FU銆佸瓡閰€?beta;-HCG鑱斿悎妫€娴嬪鍏堝厗娴佷骇鐨勮瘖鏂剰涔塠J]. 涓浗鍖昏嵂鎸囧崡,2020,18(6):165-166.
[13] 鏉ㄩ亾璐?姊佹弧瓒?闄堢鑻?琛€娓匒FU,瀛曢叜,β-HCG鑱斿悎妫€楠屽璇婃柇鍏堝厗娴佷骇鐨勪复搴婁环鍊糩J].瀹炵敤濡囩鍐呭垎娉岀數瀛愭潅蹇? 2023(033):010.
[14] 甯歌繛鍒?鐜嬭暰. 灏?alpha;-L-宀╄椈绯栬嫹閰跺绯栧翱鐥呮棭鏈熻偩鎹熷鐨勮瘖鏂环鍊糩J]. 妫€楠屽尰瀛?2012,27(6):495-499.

 

鎸囧崡鍏辫瘑

鐩稿叧浜у搧

鐩稿叧浜у搧


鍦ㄧ嚎鍜ㄨ

鍦ㄧ嚎鍜ㄨ


*娉ㄦ剰锛氳鍔″繀鍑嗙‘濉啓淇℃伅锛屾垜浠細灏藉揩涓庢偍鑱旂郴銆

鎻愪氦
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