ApoB-杞借剛铔嬬櫧B娴嬪畾璇曞墏鐩?鍏嶇柅姣旀祳娉?
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涓村簥搴旂敤
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- 娴嬪畾ApoB涔熸湁鍔╀簬楂樿剛铔嬬櫧琛€鐥囧垎鍨嬩笌璇婃柇銆傚ApoB鐨勬祴瀹氬彲鐢ㄤ簬閴村埆楂?beta;鑴傝泲鐧借鐥囧拰甯歌瀹舵棌鎬ф贩鍚堝瀷楂樿剛琛€鐥囥€傝繖涓ょ鐤剧梾铏界劧閮借〃鐜颁负琛€鑴傚紓甯革紝浣嗗畠浠殑鍙戠梾鏈哄埗鍜屾不鐤楁柟妗堝嵈鏈夋墍涓嶅悓銆傞€氳繃娴嬪畾ApoB鐨勬按骞筹紝鍖荤敓鍙互鍑嗙‘鍦拌瘖鏂繖浜涚柧鐥咃紝涓虹梾浜哄埗瀹氫釜鎬у寲鐨勬不鐤楁柟妗堛€侟/li>
- 娴嬪畾ApoB涔熷彲浣滀负浣跨敤璋冭妭琛€鑴傝嵂娌荤枟杩囩▼涓殑鍙嶅簲鐩戞祴銆傚ApoB鐨勬祴瀹氬彲鐢ㄤ簬闅忚鏈夊紓甯镐綆瀵嗗害鑴傝泲鐧借儐鍥洪唶(LDL-C)鐨勭梾浜恒€傜敱浜嶢poB鏄疞DL鐨勪富瑕佺粨鏋勮泲鐧斤紝鍏舵按骞崇殑鍙樺寲鍙洿鎺ュ弽鏄燣DL-C鐨勬按骞炽€傚洜姝わ紝閫氳繃瀹氭湡鐩戞祴ApoB鐨勬按骞筹紝鍖荤敓鍙互浜嗚В鐥呬汉LDL-C鐨勫彉鍖栨儏鍐碉紝鍙婃椂璋冩暣娌荤枟鏂规锛屼互闃叉鍔ㄨ剦绮ユ牱纭寲鐨勮繘灞曘€侟/li>
- ApoB闄嶄綆涓昏瑙佷簬鈪犲瀷楂樿剛琛€鐥囥€佷綆β鑴傝泲鐧借鐥囥€佽倽鐥呫€佽倽纭寲銆佺敳鐘惰吅鍔熻兘浜㈣繘銆佹伓鎬ц偪鐦ゃ€丄poB缂轰箯鐥囥€侀泴婵€绱犵枟娉曘€佽惀鍏讳笉鑹€侀敾鐐笺€佽嵂鐗╃枟娉曞強鎰熸煋绛夈€侟/li>
- 鍦ㄦ煇浜涙儏鍐典笅锛屽楂楾G琛€鐥囨椂锛岀敱浜嶵RL鍙婃畫绮掋€乻dLDL棰楃矑澧炲锛屾鏃 ApoB 鍚噺楂樿€岃儐鍥洪唶鍚噺鐩稿杈冨皯锛屾晠鍙嚭鐜癓DL-C姘村钩铏界劧涓嶉珮锛屼絾琛€娓匒poB姘村钩澧為珮鐨勬墍璋?quot;楂楢poB琛€鐥?quot;銆傚洜姝わ紝ApoB涓嶭DL-C鍚屾椂娴嬪畾鏈夊埄浜庝复搴 ASCVD椋庨櫓鍒ゆ柇銆侟/li>
- ApoB涓嶢poA1鐨勬瘮鍊?mdash;—ApoB/ApoA1锛欰poB鏄墍鏈夎嚧鍔ㄨ剦绮ユ牱纭寲棰楃矑鐨勪富瑕佽浆杩愪綋锛岃€孉poA1鏄竴绉嶆姉鑷村姩鑴夌播鏍风‖鍖栫殑鑴傝泲鐧斤紝璐熻矗鍦℉DL-C涓繍杈撹儐鍥洪唶銆侫poA1婵€娲诲嵉纾疯剛-鑳嗗浐閱囬叞鍩鸿浆绉婚叾(LCAT)锛岃繖鏄竴绉嶉叝鍖栬娴嗚儐鍥洪唶鐨勯叾锛屽苟澧炲姞楂樺瘑搴﹁剛铔嬬櫧鐨勮儐鍥洪唶鎵胯浇鑳藉姏銆侫poB/ApoA1鐨勬瘮鍊煎弽鏄犱簡涓ょ瀵圭珛鍔涢噺涔嬮棿鐨勫钩琛★紝杩欎釜姣斾緥瓒婂ぇ锛屽湪琛€娴嗕腑寰幆骞舵矇绉埌鍔ㄨ剦澹佷腑鐨勮儐鍥洪唶灏辫秺澶欬span style="color:hsl(212,80%,42%);">[4]銆侫poB/A1姣斿€肩殑澧為珮涓嶢SCVD椋庨櫓澧炲姞鍛堟鐩稿叧锛屼篃涓庡啝鐘跺姩鑴夌嫮绐勭殑瀛樺湪鍜屼弗閲嶇▼搴﹂珮搴︾浉鍏颤span style="color:hsl(212,80%,42%);">[5, 6]銆傜爺绌跺彂鐜帮紝涓浗閮ㄥ垎鍦板尯涓勾浜虹兢涓瑼poB/A1澧為珮鍙鍔犲績琛€绠＄柧鐥呬簨浠剁殑鍙戠敓椋庨櫓锛孉poB/A1澧為珮鍜岄珮琛€鍘嬪鍐犲績鐥呬簨浠跺叿鏈夋鐩稿姞浜や簰浣滅敤锛屽悓鏃跺瓨鍦ㄦ椂蹇冭绠＄柧鐥呬簨浠剁殑鍙戠敓椋庨櫓鏄庢樉澧炲姞[7]銆傜憺鍏哥殑涓€椤圭爺绌跺彂鐜帮紝ApoB/A1姣斿€兼瘮鍗曠嫭鐨凙poB鏇磋兘瑕嗙洊琛€鑴傚紓甯搁珮鍗变汉缇わ紝ApoB/A1姣斿€煎崌楂橈紝涓昏涓嶈壇蹇冭绠′簨浠跺彂鐢熷緱鏇存棭銆侫poB/A1姣斿€艰緝楂樼殑鎮ｈ€呮瘮杈冧綆鐨勬偅鑰呮棭鍙戠敓蹇冭绠′簨浠迭span style="color:hsl(212,80%,42%);">[8]銆侟/li>
- 琛€娴咥poB鍦ㄧ壒娈婁汉缇や腑鐨勫簲鐢?mdash;—璇勪及骞磋交鎮ｈ€呮湭鏉ュ績琛€绠￠闄╃殑鑹ソ鎸囨爣锛氬啝蹇冪梾鏃㈠線琚涓烘槸鑰佸勾鐤剧梾锛屼絾鍗婃暟鐢锋€ф偅鑰呭拰1 /3鐨勫コ鎬ф偅鑰呭績琛€绠′簨浠跺彂鐢熷湪65宀佷箣鍓嶏紝鍏朵腑40锝?0宀佺殑浜虹兢鍗犲績琛€绠′簨浠跺彂鐢熸€绘暟鐨勪富瑕侀儴鍒嗭紝鍥犳蹇呴』鏇村姞閲嶈骞磋交鎮ｈ€呯殑绛涙煡銆侷NTERHEART鐮旂┒(2016)鍙戠幇锛屼笌鑰佸勾鎮ｈ€呯浉姣旓紝琛€娴咥poB涓庡勾杞绘偅鑰呭彂鐢熷績琛€绠′簨浠堕闄╃殑鐩稿叧鎬ф洿澶с€侰ARDIA鐮旂┒(2016)鍙戠幇锛岃娴 ApoB 浣滀负鍔ㄨ剦绮ユ牱纭寲椋庨櫓鐩稿叧鐨勮鑴傛寚鏍囷紝鏈夊姪浜庤瘑鍒湪浼犵粺鍗遍櫓鍥犵礌鍑虹幇涔嬪墠鏈変腑骞村啝蹇冪梾椋庨櫓鐨勫勾杞绘偅鑰呫€備笂杩扮爺绌舵彁绀猴紝琛€娴咥poB姘村钩鏄瘎浼板勾杞绘偅鑰呮湭鏉ュ績琛€绠￠闄╃殑鑹ソ鎸囨爣锛岃鑴傚紓甯稿勾杞绘偅鑰呭敖鏃╂帴鍙楅檷鑴傛不鐤楀皢鑾风泭鏇村ぇ[9]銆侟/li>
閫傜敤绉戝
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钀ュ吇绉慄/strong> |
钀ュ吇涓嶈壇 |
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浣撴绉?浣撴涓績 |
浣撴浜虹兢绛涙煡琛€鑴傚紓甯告偅鑰匋/p> |
鍙傝€冩枃鐚?/h3>
[1] 涓浗琛€鑴傜鐞嗘寚鍗椾慨璁㈣仈鍚堜笓瀹跺鍛樹細. 涓浗琛€鑴傜鐞嗘寚鍗?2023骞?[J]. 涓浗寰幆鏉傚織,2023,38(3):237-271.
[2] 涓崕鍖诲浼氭楠屽尰瀛﹀垎浼?涓浗鍖诲笀鍗忎細妫€楠屽尰甯堝垎浼?涓浗鐢熺墿鍖栧涓庡垎瀛愮敓鐗╁浼氳剛璐ㄤ笌鑴傝泲鐧戒笓涓氬鍛樹細,绛? 涓浗涓村簥琛€鑴傛娴嬫寚鍗梉J]. 涓崕妫€楠屽尰瀛︽潅蹇?2022,45(10):1017-1033.
[3] 灏氱孩, 鐜嬫瘬涓? 鐢冲瓙鐟? 鍏ㄥ浗涓村簥妫€楠屾搷浣滆绋媅M]. 绗?鐗? 鍖椾含: 浜烘皯鍗敓鍑虹増绀? 2015.
[4] 褰皯鎬?鑻忓浗娴? 杞借剛铔嬬櫧B棰勬祴蹇冭绠＄柧鐥呴闄╃殑搴旂敤杩涘睍[J]. 鍥介檯蹇冭绠＄梾鏉傚織,2023,50(5):298-301.
[5] Tian M., et al., Comparison of Apolipoprotein B/A1 ratio, Framingham risk score and TC/HDL-c for predicting clinical outcomes in patients undergoing percutaneous coronary intervention. Lipids Health Dis. 2019 Nov 19;18(1):202.
[6] Hua R, Li Y, Li W, Wei Z, Yuan Z, Zhou J. Apolipoprotein B/A1 Ratio Is Associated with Severity of Coronary Artery Stenosis in CAD Patients but Not in Non-CAD Patients Undergoing Percutaneous Coronary Intervention. Dis Markers. 2021 Dec 18;2021:8959019.
[7] 涓浗蹇冭绠＄柧鐥呯洃娴嬨€侀闃查璀﹀拰娌荤枟鎶€鏈簲鐢ㄧ爺绌剁粍. 鎴戝浗涓勾浜虹兢杞借剛铔嬬櫧B涓庤浇鑴傝泲鐧紸-1姣斿€煎鍐犲績鐥呬簨浠堕娴嬩綔鐢ㄧ殑鐮旂┒[J]. 涓浗寰幆鏉傚織,2021,36(11):1077-1082.
[8] Walldius G., et al., Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio-Experience from the Swedish AMORIS cohort: A cohort study. PLoS Med. 2021 Dec 1;18(12):e1003853.
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