Lp(a)-鑴傝泲鐧?a)娴嬪畾璇曞墏鐩?鑳朵钩鍏嶇柅姣旀祳娉?
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璇曞墏鐩掍紭鍔军/h4>
1.鑳朵钩鍏嶇柅姣旀祳娉曪紝鎻愰珮鐏垫晱搴﹀拰鐗瑰紓鎬?/p>
2.绮惧瘑搴﹂珮锛孋V≤5%
3.绾挎€ц寖鍥村锛?0锝?000mg/L
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浜鸿娓呮牱鏈腑鐨勮剛铔嬬櫧(a)涓庤瘯鍓備腑閫傞噺鐨勭壒寮傛€ф姉浣撶粨鍚堬紝褰㈡垚涓嶆憾鎬х殑鍏嶇柅澶嶅悎鐗╋紝浣垮弽搴旀恫鍚稿厜搴︽敼鍙橈紝鍦ㄦ姉浣撻噺涓€瀹氱殑鏉′欢涓嬶紝鍚稿厜搴︾殑鏀瑰彉涓庝汉琛€娓呮牱鏈腑鑴傝泲鐧?a)鍚噺鎴愭鐩稿叧銆侟/p>
涓村簥搴旂敤
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- Lp(a)鍦ㄥ叾浠栫柧鐥呬腑鐨勭爺绌剁幇鐘讹細姝ゅ锛孡p(a)澧為珮杩樺彲瑙佷簬澶氱鐐庣棁鍙嶆槧銆佸悇绉嶆€ユ€ф椂鐩稿弽搴斻€佽偩鐥呯患鍚堝緛鍙婃參鎬ц偩鍔熻兘涓嶅叏銆佺硸灏跨梾鑲剧梾銆佸濞犲拰鏈嶇敤鐢熼暱婵€绱犵瓑銆傝偩鐥呯患鍚堝緛鍙婃參鎬ц偩鍔熻兘涓嶅叏鎮ｈ€呯殑Lp(a)姘村钩涓庡仴搴蜂汉缇ゆ瘮杈冿紝鍙彁楂?-3鍊嶏紝骞跺彈鑲惧皬鐞冩护杩囩巼鍙楁崯绋嬪害銆佹満浣撶値鐥囧弽搴斿強灏胯泲鐧芥按骞冲奖鍝岦span style="color:hsl(212,80%,42%);">[2]銆侟/li>
- 鍦ㄥ師鍙戞€ц儐姹佹€ц倽纭寲銆佽倽鐧屽強鎱㈡€т箼閱囨互鐢ㄧ瓑瀵艰嚧鑲濊“绔殑鎯呭喌涓嬶紝琛€娴哃p(a)姘村钩鍙檷浣庯紝浣嗗叾姘村钩鍙殢鐫€鑲濆姛鑳界殑鏀瑰杽鑰屾仮澶嶈嚦鍒濆鍊稽span style="color:hsl(212,80%,42%);">[3]銆侟/li>
- Lp(a)鐨勯闄╁楂樺垏鐐瑰敖绠℃湁澶ч噺鐮旂┒鎻愮ず锛孡p(a)姘村钩鍗囬珮涓嶤AD銆佽剳鍗掍腑鍜孋AVS鐩稿叧锛屽苟瀵艰嚧涓昏涓嶈壇蹇冭绠′簨浠?MACE)椋庨櫓鍗囬珮銆傞仐鎲剧殑鏄紝杩勪粖鏈夊叧Lp(a)澧炲姞CVD椋庨櫓澧為珮鐨勫垏鐐瑰€煎皻鏃犲畾璁猴紝Lp(a)鐨勯闄╁楂樺垏鐐圭殑纭畾闇€瑕佸ぇ鏍锋湰浜虹兢鐨勭郴鍒楃爺绌舵暟鎹€傚鍓嶆墍杩帮紝涓嶅悓绉嶆棌Lp(a)娴撳害瀛樺湪宸紓锛屽洜姝や笉鍚岀鏃忕殑Lp(a)椋庨櫓澧為珮鍒囩偣浜︿笉鍚屻€傘€婁腑鍥芥垚浜鸿鑴傚紓甯搁槻娌绘寚鍗?2016骞翠慨璁㈢増)銆婞span style="color:hsl(212,80%,42%);">[4]寤鸿锛屽湪鎺掗櫎鍚勭搴旀縺鎬у崌楂樼殑鎯呭喌涓嬶紝Lp(a)鍗囬珮琚涓烘槸ASCVD鐨勭嫭绔嬪嵄闄╁洜绱狅紝Lp(a)閫氬父浠?0mg/dl涓洪闄╁楂樺垏鐐癸紝楂樹簬姝ゆ按骞宠€呮偅CAD鐨勫嵄闄╂€ф槑鏄惧楂樸€傛眹鎬诲湪涓浗浜虹兢涓帰绌禠p(a)椋庨櫓鍒囩偣鐨勭爺绌讹紝澶氭暟鐮旂┒缁撴灉鏄剧ず锛孡p(a)>30mg/dl鏄啝蹇冪梾(CAD)鍜岀己琛€鎬ц剳鍗掍腑鐨勭嫭绔嬮娴嬪洜瀛愩€傚洜姝わ紝2021鐗堢殑銆婅剛铔嬬櫧(a)涓庡績琛€绠＄柧鐥呴闄╁叧绯诲強涓村簥绠＄悊鐨勪笓瀹剁瀛﹀缓璁€婞span style="color:hsl(212,80%,42%);">[1]鍩轰簬涓浗浜虹兢鐨勭幇鏈夋暟鎹紝鍊惧悜浜庢敮鎸佸皢30mg/dl浣滀负涓浗浜虹兢Lp(a)鐨勯闄╁楂樺垏鐐癸紝鍗矻p(a)瓒呰繃30mg/dl蹇冭绠＄柧鐥呴闄╁彲鑳芥€у鍔犮€侟/li>
閫傜敤绉戝
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閫傜敤绉戝 |
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鍐呯/蹇冨唴绉慄/strong> |
ASCVD鐥呭彶鍙婄‘璇婁汉缇わ紝ASCVD鏋侀珮銆佷腑鍗变汉缇わ紝绯栧翱鐥咃紝鑲ヨ儢鍙婅鑴傚紓甯革紝楂樿鍘嬶紝鍚哥儫锛屾棭鍙慉SCVD瀹舵棌鍙诧紙鐢锋€?lt;55宀侊紝濂虫€?lt;65宀侊級锛岃鑴傚紓甯稿鏃忓彶 |
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鑲惧唴绉慄/strong> |
鍚勭鎬ユ參鎬ц偩鑴忕梾 |
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鑲濊儐鍐呯 |
鍚勭鎬ユ參鎬ц倽鑴忕梾 |
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浣撴绉?浣撴涓績 |
涓€鑸汉缇わ紙姣忎釜鎴愬勾浜虹殑涓€鐢熶腑鑷冲皯搴旇€冭檻妫€1娆★級 |
鍙傝€冩枃鐚?/h3>
[1] 鍖椾含蹇冭剰瀛︿細. 鑴傝泲鐧?a)涓庡績琛€绠＄柧鐥呴闄╁叧绯诲強涓村簥绠＄悊鐨勪笓瀹剁瀛﹀缓璁甗J]. 涓浗寰幆鏉傚織,2021,36(12):1158-1167.
[2] Hopewell, J.C., R. Haynes, and C. Baigent, The role of lipoprotein (a) in chronic kidney disease. J Lipid Res, 2018. 59(4): 577-585.
[3] Kostakou, P.M., et al., Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels. Curr Med Chem, 2017. 24(10): 969-978.
[4] 涓浗鎴愪汉琛€鑴傚紓甯搁槻娌绘寚鍗椾慨璁㈣仈鍚堝鍛樹細. 涓浗鎴愪汉琛€鑴傚紓甯搁槻娌绘寚鍗?2016骞翠慨璁㈢増)[J]. 涓浗寰幆鏉傚織,2016,31(10):937-950.
鎸囧崡鍏辫瘑
