PD-1妫€娴嬭瘯鍓傜洅(娴佸紡缁嗚優浠硶)

--鑲跨槫鐨勭枟鏁堣瘎浠枫€佽緟鍔╄瘖鏂€佺柧鐥呰繘灞曟寚鏍嘃/h3>
鏍锋湰绫诲瀷锛欵DTA鎶楀嚌琛€

鏍″噯鍝侊細璇锋牴鎹墍鐢ㄦ祦寮忕粏鑳炰华鍨嬪彿閫夌敤鍘傚瑕佹眰閰嶅鐨勬牎鍑嗗搧

璐ㄦ帶鍝侊細璇锋牴鎹墍鐢ㄦ祦寮忕粏鑳炰华鍨嬪彿閫夌敤鍘傚鎺ㄨ崘鐨勮川鎺у搧

閰嶅浠櫒锛氫腑鐢烞ioCyte銆丗lowCyte/ZS-AE7S銆丗ACSCantoII銆丗ACSCalibur銆丏xFLEX銆丯avios銆丯ovoCyte銆丅riCyte E6绛夋祦寮忕粏鑳炰华

浜у搧鍜ㄨ

鑱旂郴鎴戜滑

鎸囨爣绠€浠婞/h3>
绋嬪簭鎬х粏鑳炴浜¤泲鐧? (programmed cell death protein-1锛岀畝绉癙D-1锛屼篃绉颁负CD279)锛孴缁嗚優琛ㄩ潰涓€绉嶉噸瑕佺殑鍏嶇柅鎶戝埗鍒嗗瓙锛屽睘浜嶤D28/CTLA-4 瀹舵棌锛屾槸涓€涓?88姘ㄥ熀閰告畫鍩虹殑璺ㄨ啘绯栬泲鐧斤紝鐢盤DCD1鍩哄洜缂栫爜銆傚憟璇卞鎬ц〃杈句簬娲诲寲鐨 T 缁嗚優銆丅缁嗚優鍜 NK 缁嗚優琛ㄩ潰銆侾D-1/PD-L1淇″彿閫氳矾鏄富瑕佺殑鍏嶇柅妫€鏌ョ偣閫氳矾涔嬩竴,鍦ㄥ绉嶈偪鐦ょ殑鍏嶇柅鑰愬彈鍜屽厤鐤€冮€镐腑鍙戞尌閲嶈浣滅敤[1]銆侾D-L1锛堣偪鐦ょ粏鑳炰笂鐨勶級涓嶱D-1锛堟晥搴擳缁嗚優鐨勶級缁撳悎锛屽彲浼犲鎶戝埗鎬т俊鍙凤紝浠庤€屾姂鍒禩缁嗚優鐨勫娈栨椿鍖栵紝娑堝急鑲跨槫灞€閮ㄦ蹈娑D4+CD8+T缁嗚優鐨勫姛鑳斤紝鍑忓皯缁嗚優鍥犲瓙浜х敓锛涘惎鍔═缁嗚優鐨勭▼搴忔€ф浜★紝浣胯偪鐦ょ粏鑳炶幏寰楀厤鐤€冮€搞€侟/p>

妫€娴嬪師鐞咟/h3>
娴佸紡缁嗚優浠硶锛氬緟娴嬫牱鏈殑缁嗚優鎮恫锛屽湪闉樻恫鐨勫寘鍥村拰绾︽潫涓嬶紝缁嗚優鎺掓垚鍗曞垪楂橀€熺敱娴佸姩瀹ゅ柗鍢村柗鍑猴紝褰㈡垚缁嗚優娑叉煴銆傚綋娑叉煴閫氳繃妫€娴嬪尯锛屽湪鍏ュ皠鐨勬縺鍏夋潫鐓у皠涓嬩骇鐢熷墠鍚戣鏁ｅ皠鍏夛紙FSC锛夊拰渚у悜瑙掓暎灏勫厜锛圫SC锛夛紝瀹冧滑鍒嗗埆鍙嶆槧缁嗚優澶у皬鍜岄绮掑害锛屾牴鎹繖浜涚壒鎬у彲浠ュ皢缁嗚優鍒嗙被銆傜粡涓€绉嶆垨鍑犵鐗规畩鑽у厜鏍囪鐨勬牱鏈紝鍦ㄦ縺鍏夋潫鐨勬縺鍙戜笅鎵€浜х敓鐨勭壒瀹氳崸鍏夛紝鍙鍏夊绯荤粺妫€娴嬪苟杈撻€佸埌璁＄畻鏈鸿繘琛屽垎鏋愶紝寰楀埌缁嗚優鐩稿簲鐨勫悇绉嶇壒鎬с€侟/p>

涓村簥搴旂敤

PD-1妫€娴嬪湪鐧岀棁娌荤枟棰嗗煙涓彂鎸ョ潃鍏抽敭浣滅敤锛岀壒鍒槸鍦ㄥ埄鐢≒D-1/PD-L1鍏嶇柅妫€鏌ョ偣鎶戝埗鍓傝繘琛屾不鐤楁椂銆傜爺绌朵汉鍛樻娴嬪嵉宸㈢檶缁勭粐鏍囨湰鍜岀檶鏃佹甯稿嵉宸㈢粍缁囨爣鏈殑PD-1琛ㄨ揪鍙戠幇锛屽嵉宸㈢檶缁勭粐涓璓D-1鐨勯槼鎬ц〃杈剧巼鏄庢樉楂樹簬鐧屾梺鐨勬甯稿嵉宸㈢粍缁囷紝涓旈殢鐫€鎵嬫湳鐥呯悊鍒嗘湡瓒婃櫄锛孭D-1鐨勯槼鎬ц〃杈剧巼瓒婇珮锛屾偅鑰呴鍚庤秺宸?span style="color:hsl(212,80%,42%);">[2]銆侟/li>
鍦ㄦ椿鍔ㄦ€х粨鏍哥梾浜轰腑锛孴缁嗚優銆佸崟鏍?宸ㄥ櫖缁嗚優鍙夿缁嗚優涓奝D-1銆丳D-L1鍜孭D-L2鐨勮〃杈惧潎鏄庢樉涓婂崌锛屼互PD-L1琛ㄨ揪鍗囬珮涓轰富瑕佺壒鐐广€傚叾涓璗缁嗚優涓婁互PD-1鍗囬珮涓轰富;鍗曟牳宸ㄥ櫖缁嗚優鍜孊缁嗚優浠D-L1涓轰富锛孭D-1鍜孭D-L2鐨勮〃杈句篃鍗囬珮锛岃〃杈炬按骞虫帴杩慄span style="color:hsl(212,80%,42%);">[3]銆侟/li>
PD-1涓庢不鐤楁晥鏋滆瘎浼帮細琛€娓匬D-1姘村钩瓒婇珮锛屾偅鑰呮姉PD-1鏁堟灉瓒婂樊銆侟/li>
PD-1琛ㄨ揪姘村钩涓庢墜鏈不鐤楁晥鏋滄湁鍏筹細瀵硅偤杞Щ鐦ゅ垏闄ゆ湳(PM)娌荤枟鐨勮偤杞Щ缁撶洿鑲犵檶鎮ｈ€呯殑澶栧懆琛€PD-1琛ㄨ揪鍒嗘瀽鏃讹紝PD-1浣庤〃杈炬偅鑰呯殑骞冲潎鐢熷瓨鏈熶负78涓湀锛岃€孭D-1楂樿〃杈剧殑骞冲潎鐢熷瓨鏈熷彧鏈?5涓湀銆傛彁绀猴紝PD-1闃虫€ц〃杈剧殑TIL鏄偤杞Щ缁撶洿鑲犵檶鐨勪竴绉嶆湁鏁堥鍚庢爣蹇楃墿锛屼篃鍙互閫氳繃妫€娴嬪叾姘村钩涓烘偅鑰呮槸鍚﹂€傚悎PD-1娌荤枟鎻愪緵鍙傝€冧緷鎹€侟/li>

閫傜敤绉戝

閫傜敤绉戝	瀵瑰簲鐤剧梾
鑲跨槫绉慄/strong>	PD-1鎶戝埗鍓備富瑕佺敤浜庡绉嶅疄浣撶槫鐨勬不鐤楋紝鍖呮嫭浣嗕笉闄愪簬锛欬br /> 闈炲皬缁嗚優鑲虹檶锛圢SCLC锛夈€佸皬缁嗚優鑲虹檶锛圫CLC锛夈€佽儍鑲犻亾鑲跨槫锛堝鑳冪檶鍜岀粨鐩磋偁鐧岋級銆佷钩鑵虹檶銆佹硨灏跨郴缁熻偪鐦わ紙濡傝偩鐧岋級銆佺毊鑲ょ檶锛堝榛戣壊绱犵槫锛夈€佹穻宸寸槫绛堻/p>
鍏嶇柅绉慄/strong>	鐢变簬PD-1鎶戝埗鍓傚奖鍝嶅厤鐤郴缁燂紝瀹冧滑鍙兘鍦ㄨ嚜韬厤鐤柧鐥呯殑娌荤枟涓篃鏈夋綔鍦ㄧ殑搴旂敤锛屽敖绠¤繖閫氬父涓嶆槸涓昏鐨勯€傚簲鐥囥€侟/p>
琛€娑茬	鏌愪簺绫诲瀷鐨勮娑茬郴缁熸伓鎬ц偪鐦わ紝濡傜粡鍏搁湇濂囬噾娣嬪反鐦ゅ拰鏌愪簺绫诲瀷鐨勯潪闇嶅閲戞穻宸寸槫锛屼篃鍙兘浠嶱D-1鎶戝埗鍓傛不鐤椾腑鑾风泭銆侟/p>
鑳稿绉慄/strong>	鍙兘鍙備笌鑲虹檶鎵嬫湳鎮ｈ€呯殑缁煎悎娌荤枟锛屽寘鎷湳鍓嶆垨鏈悗浣跨敤PD-1鎶戝埗鍓傘€侟/p>
鏀剧枟绉慄/strong>	鍦ㄦ煇浜涙儏鍐典笅锛孭D-1鎶戝埗鍓傚彲鑳戒笌鏀惧皠娌荤枟鑱斿悎浣跨敤锛屼互澧炲己鎶楄偪鐦ゆ晥鏋溿€侟/p>
鍏朵粬鐩稿叧绉戝	鏍规嵁鎮ｈ€呯殑鍏蜂綋鐥呮儏鍜岃偪鐦ょ被鍨嬶紝鍙兘杩樹細娑夊強鍒板叾浠栫浉鍏崇瀹わ紝濡傛硨灏垮绉戙€佸绉戠瓑銆侟/p>

鍙傝€冩枃鐚?/h3>
[1] 涓浗鎶楃檶鍗忎細鑲跨槫鐥呯悊涓撲笟濮斿憳浼氳偤鐧屽崗浣滅粍銆佸垎瀛愮梾鐞嗗崗浣滅粍, 涓浗鎶楃檶鍗忎細鑲虹檶涓撲笟濮斿憳浼? and 涓浗涓村簥鑲跨槫瀛︿細闈炲皬缁嗚優鑲虹檶涓撲笟濮斿憳浼? 闈炲皬缁嗚優鑲虹檶PD-L1琛ㄨ揪涓村簥妫€娴嬩腑鍥戒笓瀹跺叡璇?2023鐗?. 涓崕鐥呯悊瀛︽潅蹇? 2024(02): p. 121-129.
[2] 闉犵瓥, et al., PD-1鍜孭D-L1鍦ㄥ嵉宸笂鐨€х檶缁勭粐涓殑琛ㄨ揪鍙婂叾鎰忎箟. 涓崕濡囦骇绉戞潅蹇? 2020(08): p. 529-534.
[3] 鍗犵幉淇? 鍞愬啗, and 绉﹀窛, PD-1:PD-L1/PD-L2閫氳矾鍦ㄧ粨鏍告劅鏌撲腑鐨勫厤鐤綔鐢? 涓浗姣旇緝鍖诲鏉傚織, 2015. 25(07): p. 74-76.

鎸囧崡鍏辫瘑

搴忓彿	鎸囧崡/鍏辫瘑鍚嶇О	瑕佺偣
1	銆婇潪灏忕粏鑳炶偤鐧孭D-L1琛ㄨ揪涓村簥妫€娴嬩腑鍥戒笓瀹跺叡璇嗭紙2023鐗堬級銆婞/p>	鑷?018骞撮涓厤鐤鏌ョ偣鎶戝埗鍓傝幏鎵规不鐤楅潪灏忕粏鑳炶偤鐧?NSCLC)浠ユ潵锛屽浗鍐呴檰缁湁澶氫釜绋嬪簭鎬ф浜″彈浣?(programmed death1,PD-l)鍙婄▼搴忔€ф浜￠厤浣?(programmed death ligand1,PD-L1)鐨勬姉浣撹嵂鐗╄幏鎵圭敤浜嶯SCLC銆備笉鍚岃嵂鐗╁強閫傚簲璇佸PD-L1琛ㄨ揪鎻愬嚭浜嗕笉鍚岀殑妫€娴嬮渶姹傦紝鍖呮嫭浼撮殢璇婃柇銆佽ˉ鍏呰瘖鏂垨涓嶉渶瑕佹娴嬬瓑銆侟/p>
2	銆婂疄浣撹偪鐦D-L1鍏嶇柅缁勭粐鍖栧妫€娴嬩笓瀹跺叡璇嗭紙2021鐗堬級銆婞/p>	闅忕潃涓村簥瀹炶返鏁版嵁鐨勭Н绱?PD-1/PD-L1 鎶戝埗鍓傚湪澶氱鑲跨槫涓潎琚瘉瀹炴湁鏁?鐜板凡鐢ㄤ簬鍖呮嫭鑲虹檶銆侀绠＄檶銆佽儍鐧屻€佸翱璺笂鐨檶銆佽倽鐧屻€佺粨鐩磋偁鐧屻€佷钩鑵虹檶銆佺粡鍏稿瀷闇嶅閲戞穻宸寸槫鍙婃伓鎬ч粦鑹茬礌缁嗚優鐦ょ瓑鑲跨槫鐨勬不鐤椾箣涓€侟br /> PD鈥怢1妫€娴嬪浜庨儴鍒嗚偪鐦ょ殑鍏嶇柅娌荤枟鍏锋湁浼撮殢璇婃柇鍜岃ˉ鍏呰瘖鏂殑浠峰€笺€傛帹鑽愮骇鍒厾绾с€侟/p>